Wilms' tumor in adults: Aspiration cytology and cytogenetics
Wilms' tumor in adults: Aspiration cytology and cytogenetics
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DOI：
10.1002/dc.10048
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发表时间：
2002-02-01
影响因子：
1.3
通讯作者：
Yang, GCH
中科院分区：
文献类型：
--
作者：
Li, P;Perle, MA;Yang, GCH
报告1例20岁女性Wilms瘤和1例35岁男性Wilms瘤的细针吸取细胞学表现，表现为胚胎性、梭形肉瘤和罕见的上皮成分。男性患者有典型的肾肿块表现，并有肺和胸膜转移，而女性患者罕见，肿瘤起源于肾脏的包膜下肾区，并延伸至肝脏，但未侵犯肾皮质。该病例的细胞遗传学分析证实：90，XXXX，+2x3类似于4，-5，-15，-16，-17，-17，I(17)(Q10)x2。这一发现可能代表了一种与Wilms瘤相关的基因变化，这些患者发生在年长的儿科和年轻成人患者中。据我们所知，这是第六例进行细胞遗传学研究的病例，也是第一例发现成人肾母细胞瘤的等位染色体17q的病例。诊断。细胞病变。2002年；26：99-103；DOI 10.1002/DC.10048(C)2002Wiley-Liss，Inc.
The fine-needle aspiration cytologic findings of Wilms' tumor occurring in a 20-yr-old female patient and a 35-yr-old male patient showing blastemal, spindled sarcomatous and rare epithelial components are reported. The male patient had the typical presentation of renal mass with metastasis to lung and pleura, whereas the female patient had an unusual presentation with the tumor originated from the subcapsular nephrogenic zone of the kidney, extending into the liver without invasion into the renal cortex. Cytogenetic analysis of this case identified: 90, XXXX, +2x3similar to4, -5, -15, -16, -17, -17, i (17)(q10) x2. This finding may represent a genetic change associated with Wilms' tumor of older pediatric and young adult patients. To the best of our knowledge, this case is the sixth case with cytogenetic study and the first case revealing isochromosome 17q of an adult Wilms' tumor. Diagn. Cytopathol. 2002;26:99-103; DOI 10.1002/dc.10048 (C) 2002 Wiley-Liss, Inc.