Working memory deficits affect risky decision-making in methamphetamine users with attention-deficit/hyperactivity disorder
Working memory deficits affect risky decision-making in methamphetamine users with attention-deficit/hyperactivity disorder
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DOI：
10.1016/j.jpsychires.2012.01.006
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发表时间：
2012-04-01
影响因子：
4.8
通讯作者：
Grant, Igor
中科院分区：
文献类型：
--
作者：
Duarte, Nichole A.;Woods, Steven Paul;Grant, Igor
甲基苯丙胺(MA)的使用和注意力缺陷/多动障碍(ADHD)通常是同时发生的，并独立地与额纹状体环调节失调和高风险决策有关；然而，它们的共病是否会加剧高风险决策尚不清楚。这项研究评估了23名有MA依赖和ADHD病史的参与者(MA+ADHD+)，25名单独患有MA依赖(MA+ADHD-)的受试者，以及22名健康成年人(MA ADHD)，他们完成了爱荷华州赌博任务(IGT)，作为更大的神经精神病学研究评估的一部分。结果显示ADHD与ADHD之间存在显著的交互作用。MA+ADHD+队列中有工作记忆缺陷的个体表现出最强的倾向，从IGT上的“不利”与“有利”牌中选择卡片。其他精神病学、药物使用、神经内科或认知因素也无法更好地解释这种影响。研究结果表明，工作记忆缺陷可能会缓和患有ADHD的MA使用者的高风险决策表达。(C)2012爱思唯尔有限公司。保留所有权利。
Methamphetamine (MA) use and Attention-Deficit/Hyperactivity Disorder (ADHD) commonly co-occur and are independently associated with dysregulation of frontostriatal loops and risky decision-making; however, whether their comorbidity exacerbates risky decision-making is not known. This study evaluated 23 participants with histories of MA dependence and ADHD (MA+ADHD+), 25 subjects with MA dependence alone (MA+ADHD-), and 22 healthy adults (MA ADHD), who completed the Iowa Gambling Task (IGT) as part of a larger neuropsychiatric research evaluation. Results showed a significant interaction between ADHD. MA, and working memory, such that individuals with working memory deficits in the MA+ADHD+ cohort demonstrated the strongest propensity to select cards from "disadvantageous" versus "advantageous" decks on the IGT. This effect was not better explained by other psychiatric, substance use, neuromedical, or cognitive factors. Findings suggest that working memory deficits may moderate the expression of risky decision-making in MA users with ADHD. (C) 2012 Elsevier Ltd. All rights reserved.