Effects of Repeated Annual Inactivated Influenza Vaccination among Healthcare Personnel on Serum Hemagglutinin Inhibition Antibody Response to A/Perth/16/2009 (H3N2)-like virus during 2010-11
Effects of Repeated Annual Inactivated Influenza Vaccination among Healthcare Personnel on Serum Hemagglutinin Inhibition Antibody Response to A/Perth/16/2009 (H3N2)-like virus during 2010-11
复制标题
DOI：
10.1016/j.vaccine.2015.10.119
复制
发表时间：
2016-02-10
期刊：
影响因子：
5.5
通讯作者：
Gaglani, Manjusha
中科院分区：
文献类型：
--
作者：
Thompson, Mark G.;Naleway, Allison;Gaglani, Manjusha
背景资料：最近，据报道，在前一个季节或多个季节接种疫苗的人群中，流感疫苗对甲型H3 N2病毒疾病的有效性（VE）估计值较低;然而，尚不清楚这些影响是否是由于免疫原性的差异。我们对在季前收集的血清进行了血凝抑制抗体（HI）检测，类似于接种后30天，和季后赛从一个前瞻性队列的医疗保健人员（HCP）。合格的参与者至少有4年的医疗和疫苗接种记录（自2006年7月起），包括578名接受2010-11三价灭活流感疫苗[IIV 3，含有A/珀斯/16/2009-like A（H3 N2）]的HCP和209名拒绝接种疫苗的HCP。高滴度百分比估计值根据年龄、性别、种族、教育程度、家庭规模、医院护理责任和研究地点调整了既往接种次数对A/珀斯/16/2009样病毒的几何平均倍数变化率（>= 40和>100）和几何平均倍数变化率（GMR）。疫苗接种后GMR与既往疫苗接种次数呈负相关，从既往接种4次疫苗的2.3增加到既往接种0次疫苗的HCP的6.2（F[4，567] = 9.97，p < .0005）。32%的HCP与一个先前的疫苗接种达到滴度>100相比，只有11%的HCP与4个先前的疫苗接种（调整的比值比= 6.8，95%CI = 3.1 - 15.3）。结论：我们的研究结果指出，重复IIV 3疫苗接种和HI之间的关联A（H3 N2），并与最近的VE观察结果一致。最终，可能需要更好的疫苗和疫苗策略，以优化HCP和其他重复接种者的免疫原性和VE。爱思唯尔有限公司出版
Background: Recently, lower estimates of influenza vaccine effectiveness (VE) against A(H3N2) virus illness among those vaccinated during the previous season or multiple seasons have been reported; however, it is unclear whether these effects are due to differences in immunogenicity.Methods: We performed hemagglutination inhibition antibody (HI) assays on serum collected at preseason, similar to 30 days post-vaccination, and postseason from a prospective cohort of healthcare personnel (HCP). Eligible participants had medical and vaccination records for at least four years (since July, 2006), including 578 HCP who received 2010-11 trivalent inactivated influenza vaccine [IIV3, containing A/Perth/16/2009-like A(H3N2)] and 209 HCP who declined vaccination. Estimates of the percentage with high titers (>= 40 and >100) and geometric mean fold change ratios (GMRs) to A/Perth/16/2009-like virus by number of prior vaccinations were adjusted for age, sex, race, education, household size, hospital care responsibilities, and study site.Results: Post-vaccination GMRs were inversely associated with the number of prior vaccinations, increasing from 2.3 among those with 4 prior vaccinations to 6.2 among HCP with zero prior vaccinations (F[4,567] = 9.97, p < .0005). Thirty-two percent of HCP with 1 prior vaccination achieved titers >100 compared to only 11% of HCP with 4 prior vaccinations (adjusted odds ratio = 6.8, 95% CI = 3.1 - 15.3).Conclusion: Our findings point to an exposure-response association between repeated IIV3 vaccination and HI for A(H3N2) and are consistent with recent VE observations. Ultimately, better vaccines and vaccine strategies may be needed in order to optimize immunogenicity and VE for HCP and other repeated vaccinees. Published by Elsevier Ltd.