Intragastric self-infusion of ethanol by ethanol-preferring and -nonpreferring lines of rats.
Intragastric self-infusion of ethanol by ethanol-preferring and -nonpreferring lines of rats.
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通过偏好乙醇和不偏好乙醇的大鼠系进行胃内自我输注乙醇。
DOI：
10.1126/science.6539502
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Li,TK
中科院分区：
文献类型：
--
作者：
Waller,MB;McBride,WJ;Gatto,GJ;Lumeng,L;Li,TK
通过选育培育的一种偏爱乙醇的大鼠，通过自我灌胃每天每公斤体重消耗9.4±1.7克乙醇，产生每100毫升血液中乙醇浓度为92-415毫克。相比之下，乙醇非喜好品系每天自服剂量为0.7±0.2g/kg。这些发现表明，乙醇的增强作用是吸收后的，并不是由药物的气味或味道介导的。因此，大鼠的酒精偏好系可能是一种合适的酒精中毒动物模型。
An ethanol-preferring line of rats, developed by selective breeding, consumed as much as 9.4 ± 1.7 grams of ethanol per kilogram of body weight per day through intragastric self-infusions, yielding blood ethanol concentrations of 92 to 415 milligrams per 100 milliliters. By contrast, the ethanol-nonpreferring line self-administered only 0.7 ± 0.2 gram per kilogram per day. These findings indicate that the reinforcing effect of ethanol is postabsorptive and is not mediated by the drug's smell or taste. Hence the ethanol-preferring line of rats may be a suitable animal model of alcoholism.