Biological activities of recombinant human granulocyte colony stimulating factor (rhG-CSF) and tumor necrosis factor: in vivo and in vitro analysis.
Biological activities of recombinant human granulocyte colony stimulating factor (rhG-CSF) and tumor necrosis factor: in vivo and in vitro analysis.
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重组人粒细胞集落刺激因子（rhG-CSF）和肿瘤坏死因子的生物活性：体内和体外分析。
DOI：
10.1007/978-3-642-72624-8_45
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Souza,LM
中科院分区：
文献类型：
--
作者：
Moore,MA;Welte,K;Gabrilove,J;Souza,LM
在造血生长因子家族中，小鼠G-CSF首先被认为主要作用于成熟的中性粒细胞和中性粒细胞祖细胞，刺激小鼠中性粒细胞集落，其特点是体积小、成熟、频率相对较低[1,2]。G-CSF在许多小鼠组织和器官中合成，可能是由常见的巨噬细胞或内皮细胞[3]合成的，该因子已从内毒素处理小鼠的肺组织中纯化为24000 - 25000mr糖蛋白[4]。与GM-CSF和白细胞介素-3 （IL-3）不同，G-CSF对髓系白血病细胞（如WEHI-3髓单核细胞白血病细胞系[4-6]和M1髓母细胞白血病细胞系[7]）具有强大的诱导分化作用。
Within the family of hematopoietic growth factors, murine G-CSF was first recognised as acting predominantly upon mature neutrophils and neutrophil progenitors, stimulating murine neutrophil colonies characterized by small size, maturity, and relative in-frequency [1, 2]. G-CSF is synthesized in many murine tissues and organs, possibly by common populations of macrophages or endothelial cells [3], and the factor has been purified from the lung tissue of endotoxin-treated mice as a 24000–25000Mrglycoprotein [4]. In contrast to GM-CSF and interleukin-3 (IL-3), G-CSF exerts a potent differentiation-inducing action on myeloid leukemic cells such as the WEHI-3 myelomonocytic leukemic cell line [4–6] and the M1 myeloblastic leukemic line [7].