Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle
Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle
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DOI：
10.1083/jcb.201811100
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发表时间：
2019-06
期刊：
影响因子：
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通讯作者：
Yuntao Xia;C. R. Pfeifer;Kuangzheng Zhu;J. Irianto;Dazhen Liu;K. Pannell;E. J. Chen;L. Dooling;Michael P. Tobin;Mai Wang;I. Ivanovska;Lucas R. Smith;R. Greenberg;D. Discher
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文献类型：
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作者：
Yuntao Xia;C. R. Pfeifer;Kuangzheng Zhu;J. Irianto;Dazhen Liu;K. Pannell;E. J. Chen;L. Dooling;Michael P. Tobin;Mai Wang;I. Ivanovska;Lucas R. Smith;R. Greenberg;D. Discher
Xia等人的研究表明，收缩迁移会导致DNA损伤和细胞周期阻滞，这可以通过抗氧化剂加肌球蛋白II抑制或过度表达的修复因子来挽救。细胞周期进程在机械诱导的DNA损伤中表现出一个阈值。
Xia et al. show that constricted migration causes DNA damage and a cell cycle block that is rescued by antioxidant plus myosin II inhibition or overexpressed repair factors. Cell cycle progression exhibits a threshold in the mechanically induced DNA damage.