Life with 6000 genes
Life with 6000 genes
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DOI：
10.1126/science.274.5287.546
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发表时间：
1996-10-25
期刊：
影响因子：
56.9
通讯作者：
Oliver, SG
中科院分区：
文献类型：
--
作者：
Goffeau, A;Barrell, BG;Oliver, SG
通过全球合作，酿酒酵母的基因组已经完全测序。12068千碱基的序列定义了5885个潜在的蛋白质编码基因，大约140个基因指定核糖体RNA， 40个基因指定核小RNA分子，275个基因用于转移RNA。此外，完整的序列提供了有关酵母16条染色体的高级组织的信息，并使人们对它们的进化史有了一些了解。基因组显示出相当数量的明显遗传冗余，酵母基因组计划下一阶段需要解决的主要问题之一是阐明所有这些基因的生物学功能。
The genome of the yeast Saccharomyces cerevisiae has been completely sequenced through a worldwide collaboration. The sequence of 12,068 kilobases defines 5885 potential protein-encoding genes, approximately 140 genes specifying ribosomal RNA, 40 genes for small nuclear RNA molecules, and 275 transfer RNA genes. In addition, the complete sequence provides information about the higher order organization of yeast's 16 chromosomes and allows some insight into their evolutionary history. The genome shows a considerable amount of apparent genetic redundancy, and one of the major problems to be tackled during the next stage of the yeast genome project is to elucidate the biological functions of all of these genes.