Low-dose endotoxemia and human neuropsychological functions
Low-dose endotoxemia and human neuropsychological functions
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DOI：
10.1016/j.bbi.2005.04.010
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发表时间：
2005-09-01
影响因子：
15.1
通讯作者：
Bruunsgaard, H
中科院分区：
文献类型：
--
作者：
Krabbe, KS;Reichenberg, A;Bruunsgaard, H
流行病学数据表明，全身性低度炎症（定义为循环炎症介质增加2至3倍）与年龄相关的认知功能下降之间存在相关性。然而，目前尚不清楚循环细胞因子水平的小幅升高是否会对人类神经心理功能产生直接影响。我们研究了情绪，认知和炎症参数的变化，在一个实验性的体内模型的低度炎症。在一项双盲交叉研究中，12名健康的年轻男性在两个实验阶段中静脉注射大肠杆菌内毒素（0.2 ng/kg）或生理盐水之前以及之后1.5、6和24 h完成神经心理学测试。内毒素给药对体温、皮质醇水平、血压或心率没有影响，但肿瘤坏死因子（TNF）和白细胞介素（IL）-6的循环水平分别增加2-和霉菌，在3 h达到峰值，而可溶性TNF受体和IL-1受体拮抗剂在4.5 h达到峰值。中性粒细胞计数增加，淋巴细胞计数下降。在该模型中，低剂量内毒素血症并不显著影响认知表现，但陈述性记忆表现与细胞因子增加呈负相关。总之，我们的研究结果表明，循环IL-6和记忆功能之间的负相关，在非常低剂量的内毒素血症独立的身体应激症状，下丘脑-垂体-肾上腺轴。(c)2005年爱思唯尔公司All rights reserved.
Epidemiological data demonstrate an association between systemic low-grade inflammation defined as 2- to 3-fold increases in circulating inflammatory mediators and age-related decline in cognitive function. However, it is not known whether small elevations of circulating cytokine levels cause direct effects on human neuropsychological functions. We investigated changes in emotional, cognitive, and inflammatory parameters in an experimental in vivo model of low-grade inflammation. In a double-blind crossover study, 12 healthy young males completed neuropsychological tests before as well as 1.5, 6, and 24 h after an intravenous injection of Escherichia coli endotoxin (0.2 ng/kg) or saline in two experimental sessions. Endotoxin administration had no effect on body temperature, cortisol levels, blood pressure or heart rate, but circulating levels of tumor necrosis factor (TNF) and interleukin (IL)-6 increased 2- and Mold, respectively, reaching peak values at 3 h, whereas soluble TNF-receptors and IL-1 receptor antagonist peaked at 4.5 h. The neutrophil count increased and the lymphocyte count declined. In this model, low-dose endotoxemia did not affect cognitive performance significantly but declarative memory performance was inversely correlated with cytokine increases. In conclusion, our findings demonstrate a negative association between circulating IL-6 and memory functions during very low-dose endotoxemia independently of physical stress symptoms, and the hypothalamo-pituitary-adrenal axis. (c) 2005 Elsevier Inc. All rights reserved.