Impact of Olmesartan on Progression of Coronary Atherosclerosis A Serial Volumetric Intravascular Ultrasound Analysis From the OLIVUS (Impact of OLmesarten on progression of coronary atherosclerosis: evaluation by IntraVascular UltraSound) Trial
Impact of Olmesartan on Progression of Coronary Atherosclerosis A Serial Volumetric Intravascular Ultrasound Analysis From the OLIVUS (Impact of OLmesarten on progression of coronary atherosclerosis: evaluation by IntraVascular UltraSound) Trial
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DOI：
10.1016/j.jacc.2009.09.062
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发表时间：
2010-03-09
影响因子：
24
通讯作者：
Ohe, Tohru
中科院分区：
文献类型：
--
作者：
Hirohata, Atsushi;Yamamoto, Keizo;Ohe, Tohru
目的本研究的目的是评估奥美沙坦对冠状动脉粥样硬化进展的影响。先前的血管内超声（IVUS）试验结果表明，一些药物可以减缓冠状动脉粥样硬化的进展，但没有令人信服的证据表明血管紧张素- ii受体阻滞剂可以减缓冠状动脉粥样硬化的进展。方法前瞻性、随机、多中心试验olivus（奥美沙坦对冠状动脉粥样硬化进展的影响：血管内超声评价）对247例伴有先天性冠状动脉疾病的稳定型心绞痛患者进行研究。当这些患者接受经皮冠状动脉介入治疗罪魁祸首病变时，对其非罪魁祸首血管进行IVUS(没有血管造影记录的冠状动脉狭窄[
Objectives The aim of this study was to evaluate the impact of olmesartan on progression of coronary atherosclerosis.Background Prior intravascular ultrasound (IVUS) trial results suggest slowing of coronary atheroma progression with some medicines but have not shown convincing evidence of regression with angiotension-II receptor blocking agents.Methods A prospective, randomized, multicenter trial-OLIVUS (Impact of OLmesartan on progression of coronary atherosclerosis: evaluation by IntraVascular UltraSound)-was performed in 247 stable angina pectoris patients with native coronary artery disease. When these patients underwent percutaneous coronary intervention for culprit lesions, IVUS was performed in their nonculprit vessels (without angiographically documented coronary stenosis [