THE GROWING TERATOMA SYNDROME
THE GROWING TERATOMA SYNDROME
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DOI：
10.1002/1097-0142(19821015)50:8
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发表时间：
1982-01-01
期刊：
影响因子：
6.2
通讯作者：
JOHNSON, DE
中科院分区：
文献类型：
--
作者：
LOGOTHETIS, CJ;SAMUELS, ML;JOHNSON, DE
6例成功接受化疗的转移性混合生殖细胞肿瘤患者复发了孤立性扩大肿块。4例肺部肿块增大，2例腹部肿块增大。每个人都有假定的化疗难治性肿块手术切除，并发现有成熟的畸胎瘤，没有恶性组织学。2例患者的生长可归因于紧张和扩张性囊肿;其余4例患者有坚实的肿块。在5、13、14、25、66和108个月时，所有患者均保持无疾病，无需进一步治疗。早期认识到这一以前未报告的和不寻常的临床情况下，良性畸胎瘤生长后化疗将允许手术挽救。
Six patients with metastatic mixed germ‐cell tumors who had been treated successfully with chemotherapy had recurring solitary enlarging masses. Four had enlarging pulmonary masses and two patients had enlarging abdominal masses. Each had the presumed chemotherapy refractory mass surgically resected and was found to have mature teratoma with absence of malignant histologies. The growth in two patients can be attributed to tense and expansile cysts; the remaining four had firm masses. All patients remain free of disease without further therapy at 5, 13, 14, 25, 66, and 108 months. Early recognition of this previously unreported and unusual clinical circumstance of a benign teratoma to grow after chemotherapy will allow for surgical salvage.