Reference body composition in adult rhesus monkeys: Glucoregulatory and anthropometric indices
Reference body composition in adult rhesus monkeys: Glucoregulatory and anthropometric indices
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DOI：
10.1093/gerona/60.12.1518
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发表时间：
2005-12-01
影响因子：
5.1
通讯作者：
Schoeller, DA
中科院分区：
文献类型：
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作者：
Raman, A;Colman, RJ;Schoeller, DA
恒河猴已被用作研究肥胖和疾病的模型。本研究的目的是定义体重不足和肥胖的猕猴体重指数。对40只雄性和26只雌性恒河猴8-14年的纵向数据进行了分析。体重、胰岛素敏感性指数和处置指数与体脂百分比（%BF）进行回归。确定最小%BF（超过此值，体重进一步减轻导致瘦体重减轻）在老年雄性中为11.5%，成年雌性中为8%，年轻成年雄性中为9%。胰岛素敏感性指数和处置指数达到最低值时，23%的脂肪在老年男性，18%的成年女性，21%的年轻成年男性，表明肥胖。估计的%BF参考范围在雄性猴中为9%-23%，在雌性猴中为8%-18%，对应于雄性猴的体重指数为32-44 kg/m2，雌性猴的体重指数为27-35 kg/m2。
Rhesus monkeys have been used as models to study obesity and disease. The aim of this study was to define body mass indices for underweight and obesity in rhesus monkeys. Longitudinal data collected over 8-14 years from 40 male and 26 female rhesus monkeys were analyzed. Body weight, insulin sensitivity index, and disposition index were regressed against percent body fat (%BF). A minimal %BF beyond which further loss of body weight resulted in loss of lean mass was determined to be 11.5% in older mates, 8% in adult females, and 9% in younger adult males. Insulin sensitivity index and disposition index reached minimum values at 23% fat in older males, 18% in adult females, and 21% in younger adult males, indicating obesity. The estimated reference range for %BF was 9%-23% in male and 8%-18% in female monkeys, corresponding to body mass indices of 32-44 kg/m(2) for male and 27-35 kg/m(2) for female monkeys.