Vitamin D control of gene expression: Temporal and spatial parameters for organization of the regulatory machinery
Vitamin D control of gene expression: Temporal and spatial parameters for organization of the regulatory machinery
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DOI：
10.1615/critreveukargeneexpr.v18.i2.50
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发表时间：
2008-01-01
影响因子：
1.6
通讯作者：
Arriagada, Gloria
中科院分区：
文献类型：
--
作者：
Montecino, Martin;Stein, Gary S.;Arriagada, Gloria
维生素D是骨骼基因表达的主要调节器，因此有必要了解这种类固醇激素的活性与与骨骼基因调控有关的调节级联反应之间的接口。生理反应需要组合控制，而共调节蛋白决定了生物反应对生理提示的特异性。越来越明显的是，含有维生素D受体的调节复合体是动态的，而不是静态的。这些复合体组成的时间和空间上的改变提供了一种整合调控信号的机制，通过协同和拮抗来支持积极或消极的控制。核微环境中维生素D调控成分的划分支持调控活动的整合，可能是通过在与调控信号执行一致的时间框架内确定蛋白质活动的阈值。
Vitamin D is a principal modulator of skeletal gene expression, thus necessitating an understanding of interfaces between the activity of this steroid hormone and regulatory cascades that are functionally linked to the regulation of skeletal genes. Physiologic responsiveness requires combinatorial control, whereas coregulatory proteins determine the specificity of biologic responsiveness to physiologic cues. It is becoming increasingly evident that regulatory complexes containing the vitamin D receptor are dynamic rather than static. Temporal and spatial modifications in the composition of these complexes provide a mechanism for integrating regulatory signals to support positive or negative control through synergism and antagonism. Compartmentalization of components of vitamin D control in nuclear microenvironments supports the integration of regulatory activities, perhaps by establishing thresholds for protein activity in time frames that are consistent with the execution of regulatory signaling.