The relationship of adiponectin/leptin ratio with homeostasis model assessment insulin resistance index and metabolic syndrome in apparently healthy korean male adults.
The relationship of adiponectin/leptin ratio with homeostasis model assessment insulin resistance index and metabolic syndrome in apparently healthy korean male adults.
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DOI：
10.4093/kdj.2010.34.4.237
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发表时间：
2010-08
期刊：
影响因子：
--
通讯作者：
Kim SW
中科院分区：
文献类型：
--
作者：
Jung CH;Rhee EJ;Choi JH;Bae JC;Yoo SH;Kim WJ;Park CY;Mok JO;Kim CH;Lee WY;Oh KW;Park SW;Kim SW
我们调查了脂联素/瘦素（A/L）比值与心血管危险因素、胰岛素抵抗指数和代谢综合征（MS）的关系。68名男性受试者参加了年度健康检查计划（平均年龄，55.1岁）。使用生物电阻抗分析仪测量体脂百分比（%）。采用放射免疫法测定血清瘦素水平，采用酶联免疫吸附法测定脂联素水平。计算稳态模型评估（HOMA）-胰岛素抵抗（IR）指数，并评估代谢综合征的存在。脂联素、瘦素和A/L比与体脂百分比、血脂谱和HOMA-IR显着相关。MS受试者的平均瘦素和HOMA-IR水平显着较高，而A/L比显着较低。随着MS成分数量的增加，瘦素和HOMA-IR的平均值增加，A/L比下降。多元回归分析显示，HOMA-IR与甘油三酯、空腹血糖、A/L比值显著相关，而A/L比值与体重指数、HOMA-IR显著相关，调整其他因素后HOMA-IR和A/L比值均为显著预测因子。韩国男性受试者的A/L比值与血脂谱、HOMA-IR以及MS组分的存在和数量相关。
We investigated the relationships of adiponectin/leptin (A/L) ratio with cardiovascular risk factors, insulin resistance index, and metabolic syndrome (MS) in apparently healthy Korean male adults. Sixty-eight male subjects were enrolled among the participants of an annual health check-up program (mean age, 55.1 years). Percent body fat (%) was measured using a bioelectric impedance analyzer. Serum leptin level was measured via radioimmunoassay, and adiponectin level was measured using an enzyme-linked immunosorbent assay. Homeostasis model assessment (HOMA)-insulin resistance (IR) index was calculated, and the presence of metabolic syndrome was assessed. Adiponectin, leptin, and A/L ratio showed significant correlations with percent body fat, lipid profile, and HOMA-IR. Mean leptin and HOMA-IR levels were significantly higher, while A/L ratio was significantly lower in subjects with MS. With increasing number of MS components, the mean values of leptin and HOMA-IR increased and the A/L ratio decreased. In multiple regression analysis, HOMA-IR was significantly correlated with triglyceride, fasting glucose, and A/L ratio, while A/L ratio was significantly correlated with body mass index and HOMA-IR. HOMA-IR and A/L ratio were significant predictors for each other after adjustment for other factors. A/L ratio correlated well with lipid profile, HOMA-IR, and the presence and number of MS components in Korean male subjects.