Quantitative approaches of dynamic FDG-PET and PET/CT studies (dPET/CT) for the evaluation of oncological patients.
Quantitative approaches of dynamic FDG-PET and PET/CT studies (dPET/CT) for the evaluation of oncological patients.
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DOI：
10.1102/1470-7330.2012.0033
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发表时间：
2012-09-28
期刊：
影响因子：
--
通讯作者：
Strauss LG
中科院分区：
文献类型：
--
作者：
Dimitrakopoulou-Strauss A;Pan L;Strauss LG
目的：在肿瘤患者中使用[18 F]脱氧葡萄糖（FDG）进行动态正电子发射断层扫描/计算机断层扫描（dPET/CT）研究是有限的，主要局限于研究方案。然而，更广泛的应用是期望的，并且可以帮助在治疗后早期评估小的治疗效果以及区分肿瘤和非肿瘤病变之间的边界差异，例如，脂肪瘤与低度脂肪肉瘤。目的是提出可用于与参数成像相结合的dPET/CT系列评价的量化方法，并证明肿瘤诊断和治疗管理的可行性。方法：60分钟的数据采集和短采集协议（20分钟的动态系列和静态图像60分钟后注射）进行了讨论。一个修改后的两个组织房室模型和非房室方法从混沌理论（分形维数的时间-活性曲线）的组合。融合的PET/CT图像以及与CT或PET/标准化摄取值图像融合的基于回归的参数图像被证明用于感兴趣体积的精确放置。结果如下：双组织房室方法导致5个动力学参数的计算，即分数血量VB（也称为分布体积）和转运速率k1至k4。此外，根据Patlak的流入量可以从运输速率计算。时间-活度曲线的分形维数描述了示踪剂分布的不均匀性。FDG的基于回归的参数图像的使用有助于可视化转运/灌注和转运/磷酸化依赖的FDG摄取，并且为现有的常规PET或PET/CT图像添加了新的维度。结论：更复杂的量化方法和专用软件以及高计算能力和更快的采集协议可以促进dPET/CT的评估，并且可以在临床常规中找到用途，特别是用于评估早期治疗效果或与新一代PET/CT扫描仪相结合的新治疗方案。
Objectives: The use of dynamic positron emission tomography/computed tomography (dPET/CT) studies with [18F]deoxyglucose (FDG) in oncological patients is limited and primarily confined to research protocols. A more widespread application is, however, desirable, and may help to assess small therapeutic effects early after therapy as well as to differentiate borderline differences between tumour and non-tumour lesions, e.g., lipomas versus low-grade liposarcomas. The aim is to present quantification approaches that can be used for the evaluation of dPET/CT series in combination with parametric imaging and to demonstrate the feasibility with regard to tumour diagnostics and therapy management. Methods: A 60-min data acquisition and short acquisition protocols (20-min dynamic series and a static image 60 min post injection) are discussed. A combination of a modified two-tissue compartment model and non-compartmental approaches from the chaos theory (fractal dimension of the time–activity curves) are presented. Fused PET/CT images as well as regression-based parametric images fused with CT or with PET/standardised uptake value images are demonstrated for the exact placement of volumes of interest. Results: The two-tissue compartmental method results in the calculation of 5 kinetic parameters, the fractional blood volume VB (known also as the distribution volume), and the transport rates k1 to k4. Furthermore, the influx according to Patlak can be calculated from the transport rates. The fractal dimension of the time–activity curves describes the heterogeneity of the tracer distribution. The use of the regression-based parametric images of FDG helps to visualise the transport/perfusion and the transport/phosphorylation-dependent FDG uptake, and adds a new dimension to the existing conventional PET or PET/CT images. Conclusions: More sophisticated quantification methods and dedicated software as well as high computational power and faster acquisition protocols can facilitate the assessment of dPET/CT, and may find use in clinical routine, in particular for the assessment of early therapeutic effects or new treatment protocols in combination with the new generation of PET/CT scanners.
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影响因子：
3
作者：
MIYAZAWA, H;OSMONT, A;BARON, JC
通讯作者：
BARON, JC
影响因子：
3.3
作者：
Oka, K;Kumasaka, S;Kashima, I
通讯作者：
Kashima, I
影响因子：
3.1
作者：
Dimitrakopoulou-Strauss, Antonia;Hoffmann, Martin;Strauss, Ludwig G.
通讯作者：
Strauss, Ludwig G.
DOI：
10.1007/s00259-011-1776-2
发表时间：
2011-07-01
影响因子：
9.1
作者：
Apostolopoulos, Dimitris J.;Dimitrakopoulou-Strauss, Antonia;Strauss, Ludwig G.
通讯作者：
Strauss, Ludwig G.
影响因子：
2.2
作者：
Dougherty, G
通讯作者：
Dougherty, G