The action of retrorsine on rat's liver
The action of retrorsine on rat's liver
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逆转录碱对大鼠肝脏的作用
DOI：
10.1002/path.1700400208
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发表时间：
1935
期刊：
影响因子：
--
通讯作者：
J. Davidson
中科院分区：
文献类型：
--
作者：
J. Davidson
在饲养家畜的国家，在摄入某些种类的马和牛之后发生肝硬化是一种比较常见的疾病。在新斯科舍省，它被称为皮克图病，在新西兰被称为温顿病，而在南非，有一种致命的疾病被称为Molten0病和“dunsiekte”。在英国（Cushny and Watt, 1920），牛中也曾爆发过这种疾病，这些牛食用了大量的Senecio jacoba（普通的ragwort）。这个物种在挪威很丰富，那里的牛死于一种叫做“Sirasyke”的疾病，这种疾病具有senecio中毒的特征症状。1920年，威尔莫特和罗伯逊报告了发生在开普省一个地区较贫穷的白人中的11例病例。大多数是儿童感染，而且是致命的，这显然是由于小麦被一种小麦种子污染了。受感染动物的症状在所有国家都是相似的。食欲不振，体重减轻，并伴有腹泻。可能出现消瘦和腹水，动物站立和行走困难。随后出现大脑症状，难以保持平衡，步履蹒跚。可能会有明显的狂热。随后昏迷，在观察到最初症状后几天死亡。这种病通常不发烧。尸检显示黏膜有一定程度的黄疸。肝脏表面凹凸不平，用刀切开时组织很坚硬。显微镜检查显示了这个过程的不同阶段。在较急性和早期的类型中，小叶中央静脉周围有血液外渗。这些被称为“血池”或“血湖”。这些区域附近的肝细胞退化消失。在晚期有明确的纤维化，Theiler称之为“间质性肝炎”。肝脏的正常结构丧失，细胞被纤维组织所取代，
CIRRHOSIS of the liver following the ingestion of certain species of the genus Senecio is a comparatively common disease amongst horses and cattle in stock-raising countries. In Nova Scotia it is known as Pictou disease, in New Zealand as Winton disease, while in South Africa there are fatal conditions known as Molten0 disease and “dunsiekte.” There has also been an outbreak in England (Cushny and Watt 1920) amongst cattle which had consumed a quantity of the species Senecio jacobEa (the common ragwort). This species is abundant in Norway where the cattle die of a disease known as “Sirasyke,” which has the characteristic symptoms of senecio poisoning. I n 1920 Willmot and Robertson reported eleven cases which had occurred in the poorer white population of a district in the Cape Province. The majority were in children and were fatal, This was apparently due to the contamination of wheat by seed from a species of senecio. The symptoms in the affected animals are similar in all countries. There is loss of appetite and weight, accompanied by diarrhea. Emaciation and ascites may be present and the animal has difEculty in standing and walking. Cerebral symptoms supervene, with difficulty in the maintenance of balance and a staggering gait. There may be marked frenzy. Coma follows and death occurs a few days after the first symptoms are observed. The disease is usually afebrile.Post-mortem examination shows a certain amount of jaundice of the mucosze. The surface of the liver is uneven and the tissue is tough when cut by the knife. Microscopic examination reveals various stages of the process. In the more acute and early types there is extravasation of blood round the central veins of the lobules. These have been called “blood pools” or “blood lagoons.” The liver cells in the vicinity of these areas degenerate and disappear. In the later stages there is a definite fibrosis which Theiler has called an “interstitial hepatitis.” There is a loss of the normal architecture of the liver and the cells are replaced by fibrous tissue,