Vitamin D level and risk of community-acquired pneumonia and sepsis.
Vitamin D level and risk of community-acquired pneumonia and sepsis.
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DOI：
10.3390/nu6062196
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发表时间：
2014-06-10
期刊：
影响因子：
5.9
通讯作者：
Chonchol M
中科院分区：
文献类型：
--
作者：
Jovanovich AJ;Ginde AA;Holmen J;Jablonski K;Allyn RL;Kendrick J;Chonchol M
此前的研究报告称，血清25-羟基维生素D(25(OH)D)水平降低与急性感染性疾病有关。在急性感染性疾病之前测量的维生素D状态与社区获得性肺炎(CAP)和败血症的风险之间的关系尚未被研究。社区生活的CAP或脓毒症患者的年龄、性别、种族和季节与对照组匹配。ICD-9编码确认为CAP和脓毒症；胸片确认为CAP。在入院前15个月测量血清25(OH)D水平。经糖尿病、肾脏疾病和外周血管疾病调整后的回归模型评估了25(OH)D水平与CAP或脓毒症风险的关系。132例CAP患者和对照组的年龄为60±17岁，其中71%为女性，86%为高加索人。25(OH)D水平和37nmol/L(调整后的优势比(OR)为2.57，95%可信区间为1.08-6.08)与CAP住院几率的增加密切相关。422例脓毒症患者和对照组的年龄为65±14岁，其中59%为女性，91%为高加索人。25(OH)D水平和37 nmol/L(调整后的OR1.75，95%可信区间1.11-2.77)与脓毒症住院几率增加相关。在社区生活的成年人群中，维生素D状况与CAP和败血症住院的风险呈负相关。需要进一步的临床试验来评估补充维生素D是否可以降低感染的风险，包括CAP和脓毒症。
Previous research has reported reduced serum 25-hydroxyvitamin D (25(OH)D) levels is associated with acute infectious illness. The relationship between vitamin D status, measured prior to acute infectious illness, with risk of community-acquired pneumonia (CAP) and sepsis has not been examined. Community-living individuals hospitalized with CAP or sepsis were age-, sex-, race-, and season-matched with controls. ICD-9 codes identified CAP and sepsis; chest radiograph confirmed CAP. Serum 25(OH)D levels were measured up to 15 months prior to hospitalization. Regression models adjusted for diabetes, renal disease, and peripheral vascular disease evaluated the association of 25(OH)D levels with CAP or sepsis risk. A total of 132 CAP patients and controls were 60 ± 17 years, 71% female, and 86% Caucasian. The 25(OH)D levels <37 nmol/L (adjusted odds ratio (OR) 2.57, 95% CI 1.08–6.08) were strongly associated with increased odds of CAP hospitalization. A total of 422 sepsis patients and controls were 65 ± 14 years, 59% female, and 91% Caucasian. The 25(OH)D levels <37 nmol/L (adjusted OR 1.75, 95% CI 1.11–2.77) were associated with increased odds of sepsis hospitalization. Vitamin D status was inversely associated with risk of CAP and sepsis hospitalization in a community-living adult population. Further clinical trials are needed to evaluate whether vitamin D supplementation can reduce risk of infections, including CAP and sepsis.
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在重症监护开始时，低血清25-羟基维生素D与死亡率增加有关。
影响因子：
8.8
作者：
Braun AB;Gibbons FK;Litonjua AA;Giovannucci E;Christopher KB
通讯作者：
Christopher KB
影响因子：
3.2
作者：
BUKOSKI, RD;XUE, H
通讯作者：
XUE, H
DOI：
10.1161/atvbaha.108.165886
发表时间：
2008-06-01
影响因子：
8.7
作者：
Melamed, Michal L.;Muntner, Paul;Raggi, Paolo
通讯作者：
Raggi, Paolo
影响因子：
56.9
作者：
Liu, PT;Stenger, S;Modlin, RL
通讯作者：
Modlin, RL
影响因子：
--
作者：
Ginde, Adit A.;Mansbach, Jonathan M.;Camargo, Carlos A., Jr.
通讯作者：
Camargo, Carlos A., Jr.