The genetics of Caenorhabditis elegans.
The genetics of Caenorhabditis elegans.
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作者：
S. Brenner
描述了一种小型自由生活线虫--秀丽线虫突变体的分离、互补和定位方法。大约300个EMS诱导的影响行为和形态的突变体已经被鉴定，大约100个基因已经被定义。其中77个基因的突变改变了动物的运动。对可见突变体和X染色体致死的诱发突变频率的估计表明，就像果蝇一样，线虫的遗传单位很大。
Methods are described for the isolation, complementation and mapping of mutants of Caenorhabditis elegans, a small free-living nematode worm. About 300 EMS-induced mutants affecting behavior and morphology have been characterized and about one hundred genes have been defined. Mutations in 77 of these alter the movement of the animal. Estimates of the induced mutation frequency of both the visible mutants and X chromosome lethals suggests that, just as in Drosophila, the genetic units in C. elegans are large.