SYNTHESIS + PROPERTIES OF ANALGESIC DL-ALPHA-1,3-DIMETHYL-4-PHENYL-4-PROPIONOXYAZACYCLOHEPTANE ( PROHEPTAZINE )
SYNTHESIS + PROPERTIES OF ANALGESIC DL-ALPHA-1,3-DIMETHYL-4-PHENYL-4-PROPIONOXYAZACYCLOHEPTANE ( PROHEPTAZINE )
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DOI：
10.1021/jm00331a013
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发表时间：
1964-01-01
影响因子：
7.3
通讯作者：
BRUCE, WF
中科院分区：
文献类型：
--
作者：
DIAMOND, J;TYSON, FT;BRUCE, WF
本文介绍了止痛药丙庚嗪的合成和结构证明。讨论了支持反式Me/Ph构型的证据。研究表明，在氮杂环庚烷系列中，止痛活性的增加并不一定伴随着成瘾倾向的增加。
A synthesis and proof of structure of the analgesic proheptazine are described. Evidence supporting a trans-Me/Ph configuration for proheptazine is discussed. Studies are presented to show that in the azacycloheptane series, increase in analgesic activity is not necessarily accompanied by a parallel increase in addiction liability.