Association between breast cancer and allostatic load by race: National Health and Nutrition Examination Survey 1999-2008
Association between breast cancer and allostatic load by race: National Health and Nutrition Examination Survey 1999-2008
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DOI：
10.1002/pon.3044
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发表时间：
2013-03-01
期刊：
影响因子：
3.6
通讯作者：
Palermo, Tia
中科院分区：
文献类型：
--
作者：
Parente, Victoria;Hale, Lauren;Palermo, Tia
背景资料：乳腺癌及其治疗会给诊断为乳腺癌的女性带来许多生理、心理、社会和经济压力。非稳态负荷是代表生理失调的生物标志物的综合评分，可作为乳腺癌生物负荷的衡量指标。本研究探讨乳腺癌和非稳态负荷得分之间的关联，通过比较非稳态负荷得分在那些有乳腺癌的历史，那些没有，分层的race.Methods：黑人和白色妇女年龄在35至85岁进行了分析，使用NHANES 1999-2008年的数据（n = 4875名妇女，其中188名妇女有乳腺癌的历史）。按种族分层，我们进行了多变量分析，将乳腺癌史作为非稳态负荷升高的预测因素，同时调整了其他潜在的混杂变量。虽然乳腺癌史与白色女性的非稳态负荷升高无关，但在调整年龄、收入、教育、保险类型、吸烟状况、酒精摄入和体力活动[比值比（OR）2.08（95%CI 1.02，4.22）]。此外，黑人和有乳腺癌史之间的相互作用被认为是显着的预测升高的非稳态负荷分数调整后的人口统计学，行为，和comorbiliary characteristics.Conclusions：这些结果表明，乳腺癌的生物收费可能是更大的黑人妇女比白色妇女。版权所有（C）2012约翰威利父子有限公司
Background: Breast cancer and its treatment introduce numerous physiologic, psychological, social, and economic stressors to a woman with the diagnosis. Allostatic load, a composite score of biomarkers representing physiologic dysregulation, may serve as a measure of the biological burden of breast cancer. This study investigates the association between breast cancer and allostatic load scores by comparing allostatic load scores in those with a history of breast cancer to those without, stratified by race.Methods: Black and white women aged 35 to 85 were analyzed using the data from NHANES 1999-2008 (n = 4875 women, of which 188 women had a history of breast cancer). Stratified by race, we ran multivariate analyses with history of breast cancer as a predictor for elevated allostatic load while adjusting for other potentially confounding variables.Results: Although a history of breast cancer was not associated with elevated allostatic load in white women, it was significantly associated with elevated allostatic load in black women after adjusting for age, income, education, insurance type, smoking status, alcohol intake, and physical activity [Odds Ratio (OR) 2.08 (95% CI 1.02, 4.22)]. Furthermore, an interaction between black and having a history of breast cancer was found to be significant in predicting elevated allostatic load scores after adjusting for demographic, behavioral, and comorbidity characteristics.Conclusions: These results suggest that the biological toll of breast cancer may be greater in black women than white women. Copyright (C) 2012 John Wiley & Sons, Ltd.