Dual-Action Cancer Therapy with Targeted Porous Silicon Nanovectors
Dual-Action Cancer Therapy with Targeted Porous Silicon Nanovectors
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DOI：
10.1002/smll.201701201
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发表时间：
2017-08-04
期刊：
影响因子：
13.3
通讯作者：
Voelcker, Nicolas H.
中科院分区：
文献类型：
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作者：
Cifuentes-Rius, Anna;Ivask, Angela;Voelcker, Nicolas H.
迫切需要开发更有效的治疗方法来对抗癌症。田园诗般的化疗有望克服肿瘤的耐药性，并将对健康组织的有害副作用降至最低。开发了负载有化疗药物和金纳米簇（AuNC）的组合的抗体功能化多孔硅纳米颗粒。观察到这些纳米载体选择性地将有效载荷（化疗药物和AuNC）递送至人B细胞。AuNC向靶细胞的积累以及随后暴露于微波区域中的外部电磁场使它们对共同递送的药物更敏感。这种方法代表了一种靶向的两阶段递送纳米载体，其受益于导致增强的细胞毒性的双重治疗作用。
There is a pressing need to develop more effective therapeutics to fight cancer. An idyllic chemotherapeutic is expected to overcome drug resistance of tumors and minimize harmful side effects to healthy tissues. Antibody-functionalized porous silicon nanoparticles loaded with a combination of chemotherapy drug and gold nanoclusters (AuNCs) are developed. These nanocarriers are observed to selectively deliver both payloads, the chemotherapy drug and AuNCs, to human B cells. The accumulation of AuNCs to target cells and subsequent exposure to an external electromagnetic field in the microwave region render them more susceptible to the codelivered drug. This approach represents a targeted two-stage delivery nanocarrier that benefits from a dual therapeutic action that results in enhanced cytotoxicity.