One step purification process for no-carrier-added 64Cu produced using enriched nickel target
One step purification process for no-carrier-added 64Cu produced using enriched nickel target
复制标题
DOI：
10.1524/ract.2011.1821
复制
发表时间：
2011-01-01
影响因子：
1.8
通讯作者：
Haddad, F.
中科院分区：
文献类型：
--
作者：
Alliot, C.;Michel, N.;Haddad, F.
Copper-64 在正电子发射断层扫描 (PET) 中具有多种应用。其半衰期允许将其用于与癌症治疗中铜 67 靶向放射治疗相关的剂量学研究。已知利用Ni-64(p,n)Cu-64核反应可大量产生具有高比活度的64Cu。在这项研究中，目标是通过电镀到金背衬上获得的，典型的目标辐射在 30 分钟内使用 200 nA、17MeV 质子。辐照后，仅使用一根色谱柱即可获得纯铜 64。镍 64 在第一个洗脱步骤中被去除，钴同位素在第二个洗脱步骤中被去除。 Copper-64 的萃取率为 92 +/- 3%，镍和钴杂质均在检测限以下。还开发了镍64的回收工艺。
Copper-64 has found many applications in positron emission tomography (PET). Its half-life allows to use it for dosimetric studies associated to copper-67 targeted radiotherapy in cancer treatment. The use of Ni-64(p, n)Cu-64 nuclear reaction is known to produce 64Cu in large amount and with a high specific activity. In this study, targets were obtained by electroplating onto a gold backing and a typical target irradiation uses 200 nA, 17MeV protons during 30 min. After irradiation, pure copper-64 is obtained using only one chromatographic column. Nickel-64 is removed in a first elution step and cobalt isotopes in a second one. The extraction yield for copper-64 is 92 +/- 3% and nickel and cobalt impurities are under the detection limit. A recovery process of nickel-64 has also been developed.