Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as Low-penetrance Alleles in German and Italian Familial Breast Cancer Cases
Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as Low-penetrance Alleles in German and Italian Familial Breast Cancer Cases
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DOI：
10.1002/humu.21141
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发表时间：
2010-01-01
期刊：
影响因子：
3.9
通讯作者：
Peterlongo, Paolo
中科院分区：
文献类型：
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作者：
Catucci, Irene;Yang, Rongxi;Peterlongo, Paolo
最近，据报道，hsa-mir-196 a2中的SNP rs 11614913和hsa-mir-499中的SNP rs3746444与乳腺癌风险增加相关，并且hsa-mir-146 a中的SNP rs 2910164显示出对乳腺癌诊断年龄有影响。为了进一步研究这些SNPs的作用，我们对来自德国和意大利的1894例BRCA 1和BRCA 2致病突变或未分类变异阴性的乳腺癌病例以及2760例对照进行了基因分型。我们比较了德国和意大利系列以及两个系列合并的病例与对照中rs 2910164、rs 11614913和rs3746444的基因型和等位基因频率;我们还调查了这三个SNP对乳腺癌诊断时年龄的影响。进行的分析均未显示统计学显著性结果。总之，我们的数据表明SNPs rs 2910164、rs 11614913和rs3746444与乳腺癌风险或乳腺癌发病年龄之间缺乏关联。(C)2009 Wiley-Liss，Inc.
Recently, the SNPs rs11614913 in hsa-mir-196a2 and rs3746444 in hsa-mir-499 were reported to be associated with increased breast cancer risk, and the SNP rs2910164 in hsa-mir-146a was shown to have an effect on age of breast cancer diagnosis. In order to further investigate the effect of these SNPs, we genotyped a total of 1894 breast cancer cases negative for disease-causing mutations or unclassified variants in BRCA1 and BRCA2, and 2760 controls from Germany and Italy. We compared the genotype and allele frequencies of rs2910164, rs11614913 and rs3746444 in cases versus controls of the German and Italian series, and of the two series combined; we also investigated the effect of the three SNPs on age at breast cancer diagnosis. None of the performed analyses showed statistically significant results. In conclusion, our data suggested lack of association between SNPs rs2910164, rs11614913 and rs3746444 and breast cancer risk, or age at breast cancer onset. (C) 2009 Wiley-Liss, Inc.