Dysregulated Inflammation During Obesity: Driving Disease Severity in Influenza Virus and SARS-CoV-2 Infections.
Dysregulated Inflammation During Obesity: Driving Disease Severity in Influenza Virus and SARS-CoV-2 Infections.
复制标题
DOI：
10.3389/fimmu.2021.770066
复制
发表时间：
2021
影响因子：
7.3
通讯作者：
Labzin LI
中科院分区：
文献类型：
--
作者：
Hulme KD;Noye EC;Short KR;Labzin LI
急性炎症是病毒感染过程中重要的宿主防御反应。当失调时，炎症会导致免疫病理和组织损伤。过度的破坏性炎症是甲型流感大流行病毒（IAV）感染和严重急性呼吸综合征-冠状病毒-2 （SARS-CoV-2）感染的特征。慢性、低度炎症也是肥胖的一个特征。近年来，肥胖已被认为是一种日益严重的流行病，具有很高的死亡率和相关成本。肥胖也是IAV和SARS-CoV-2感染期间疾病严重程度和死亡增加的独立危险因素。这篇综述的重点是在病毒性呼吸道感染的背景下，肥胖对炎症反应的影响，以及这是如何导致病毒病理增加的。在这里，我们将回顾炎症的基础知识，它是如何在IAV和SARS-CoV-2感染中启动的，以及它与疾病严重程度的联系。我们将研究肥胖如何驱动慢性炎症和训练免疫，以及这些如何影响对IAV和SARS-CoV-2的免疫反应。最后，我们回顾了肥胖的医疗和非医疗干预措施，它们如何影响炎症反应，以及它们如何用于预防肥胖患者的疾病严重程度。由于对全球肥胖人数的预测没有显示出放缓的迹象，未来的大流行防范将要求我们考虑人口的代谢健康。此外，如果减肥本身不足以降低呼吸道病毒相关死亡率增加的风险，则必须密切关注患者的健康史，并确定新的治疗方案。
Acute inflammation is a critical host defense response during viral infection. When dysregulated, inflammation drives immunopathology and tissue damage. Excessive, damaging inflammation is a hallmark of both pandemic influenza A virus (IAV) infections and Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) infections. Chronic, low-grade inflammation is also a feature of obesity. In recent years, obesity has been recognized as a growing pandemic with significant mortality and associated costs. Obesity is also an independent risk factor for increased disease severity and death during both IAV and SARS-CoV-2 infection. This review focuses on the effect of obesity on the inflammatory response in the context of viral respiratory infections and how this leads to increased viral pathology. Here, we will review the fundamentals of inflammation, how it is initiated in IAV and SARS-CoV-2 infection and its link to disease severity. We will examine how obesity drives chronic inflammation and trained immunity and how these impact the immune response to IAV and SARS-CoV-2. Finally, we review both medical and non-medical interventions for obesity, how they impact on the inflammatory response and how they could be used to prevent disease severity in obese patients. As projections of global obesity numbers show no sign of slowing down, future pandemic preparedness will require us to consider the metabolic health of the population. Furthermore, if weight-loss alone is insufficient to reduce the risk of increased respiratory virus-related mortality, closer attention must be paid to a patient’s history of health, and new therapeutic options identified.
登录
查看更多内容
危及生命的Covid-19患者中针对I型IFN的自身抗体。
DOI：
10.1126/science.abd4585
发表时间：
2020-10-23
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bastard P;Rosen LB;Zhang Q;Michailidis E;Hoffmann HH;Zhang Y;Dorgham K;Philippot Q;Rosain J;Béziat V;Manry J;Shaw E;Haljasmägi L;Peterson P;Lorenzo L;Bizien L;Trouillet-Assant S;Dobbs K;de Jesus AA;Belot A;Kallaste A;Catherinot E;Tandjaoui-Lambiotte Y;Le Pen J;Kerner G;Bigio B;Seeleuthner Y;Yang R;Bolze A;Spaan AN;Delmonte OM;Abers MS;Aiuti A;Casari G;Lampasona V;Piemonti L;Ciceri F;Bilguvar K;Lifton RP;Vasse M;Smadja DM;Migaud M;Hadjadj J;Terrier B;Duffy D;Quintana-Murci L;van de Beek D;Roussel L;Vinh DC;Tangye SG;Haerynck F;Dalmau D;Martinez-Picado J;Brodin P;Nussenzweig MC;Boisson-Dupuis S;Rodríguez-Gallego C;Vogt G;Mogensen TH;Oler AJ;Gu J;Burbelo PD;Cohen JI;Biondi A;Bettini LR;D'Angio M;Bonfanti P;Rossignol P;Mayaux J;Rieux-Laucat F;Husebye ES;Fusco F;Ursini MV;Imberti L;Sottini A;Paghera S;Quiros-Roldan E;Rossi C;Castagnoli R;Montagna D;Licari A;Marseglia GL;Duval X;Ghosn J;HGID Lab;NIAID-USUHS Immune Response to COVID Group;COVID Clinicians;COVID-STORM Clinicians;Imagine COVID Group;French COVID Cohort Study Group;Milieu Intérieur Consortium;CoV-Contact Cohort;Amsterdam UMC Covid-19 Biobank;COVID Human Genetic Effort;Tsang JS;Goldbach-Mansky R;Kisand K;Lionakis MS;Puel A;Zhang SY;Holland SM;Gorochov G;Jouanguy E;Rice CM;Cobat A;Notarangelo LD;Abel L;Su HC;Casanova JL
通讯作者：
Casanova JL
影响因子：
5.8
作者：
Carolan, Eirin;Hogan, Andrew E.;O'Shea, Donal
通讯作者：
O'Shea, Donal
影响因子：
56.9
作者：
Bauernfried, Stefan;Scherr, Matthias J.;Hornung, Veit
通讯作者：
Hornung, Veit
影响因子：
64.5
作者：
Bekkering, Siroon;Arts, Rob J. W.;Netea, Mihai G.
通讯作者：
Netea, Mihai G.
影响因子：
56.9
作者：
Broggi, Achille;Ghosh, Sreya;Zanoni, Ivan
通讯作者：
Zanoni, Ivan