Turning on and off recurrent balanced cortical activity
Turning on and off recurrent balanced cortical activity
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DOI：
10.1038/nature01616
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发表时间：
2003-05-15
期刊：
影响因子：
64.8
通讯作者：
McCormick, DA
中科院分区：
文献类型：
--
作者：
Shu, YS;Hasenstaub, A;McCormick, DA
绝大多数与大脑皮层神经元的突触连接都来自其他皮质神经元，既有兴奋性的，也有抑制性的，形成了局部和远程的“递归”网络。虽然这是大脑皮层组织的一个基本主题，但它的研究主要局限于理论研究，这些研究预测局部经常性网络在经常性兴奋和抑制之间显示出比例或平衡，允许产生稳定的活动期(1-5)。这种重复的活动可能是短期记忆(4，6，7)、注意力调节神经元兴奋性(8，9)和睡眠中自发活动(5，10-14)等不同操作的基础。在这里，我们证明了局部皮层回路确实通过局部循环连接产生的兴奋和抑制的比例平衡来工作，并且这种回路的工作可以产生自我维持的活动，可以通过突触输入来开启和关闭。这些结果证实了反复活动作为大脑皮层基本操作的长期假设作用。
The vast majority of synaptic connections onto neurons in the cerebral cortex arise from other cortical neurons, both excitatory and inhibitory, forming local and distant 'recurrent' networks. Although this is a basic theme of cortical organization, its study has been limited largely to theoretical investigations, which predict that local recurrent networks show a proportionality or balance between recurrent excitation and inhibition, allowing the generation of stable periods of activity(1-5). This recurrent activity might underlie such diverse operations as short-term memory(4,6,7), the modulation of neuronal excitability with attention(8,9), and the generation of spontaneous activity during sleep(5,10-14). Here we show that local cortical circuits do indeed operate through a proportional balance of excitation and inhibition generated through local recurrent connections, and that the operation of such circuits can generate self-sustaining activity that can be turned on and off by synaptic inputs. These results confirm the long-hypothesized role of recurrent activity as a basic operation of the cerebral cortex.