Visual Fields in Young Children Treated with Vigabatrin
Visual Fields in Young Children Treated with Vigabatrin
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DOI：
10.1097/opx.0b013e3181a7b3fc
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发表时间：
2009-06-01
影响因子：
1.4
通讯作者：
Fulton, Anne B.
中科院分区：
文献类型：
--
作者：
Agrawal, Shivi;Mayer, D. Luisa;Fulton, Anne B.
目的.评价白色球动态视野检查（WSKP）作为有癫痫病史并接受氨己烯酸（VGB）治疗的幼儿周边视野检查的价值。VGB是一种抗癫痫药物，与视野收缩有关。招募了31名VGB患者和10名对照受试者，中位年龄为6岁。用6个白色球和WSKP（Quinn等人用于研究早产儿视网膜病变儿童视野范围的方法）测试大斜子午线的视野范围。对于有能力的人，使用戈德曼动态视野检查（GKP; 1.7度目标）对相同的经皮进行测试。进行单眼和双眼测试。比较VGB患者和对照组WSKP和GKP的视野范围。31例VGB患者中有28例可进行双眼WSKP检查，其中位视野范围小于对照组。28例VGB患者中有8例（29%）双眼视野范围小于对照组的最小值。单眼WSKP结果在VGB患者和对照受试者之间没有差异。9例VGB患者WSKP和GKP均可检测;两种检测的视野范围无差异。WSKP在VGB患者中是可行的，即使在发育迟缓的患者中也是如此。WSKP有可能检测与VGB使用相关的视野收缩。（Optom维斯科学2009; 86：767 - 773）
Purpose. To evaluate white sphere kinetic perimetry (WSKP) as a test of the peripheral visual field in young children with a history of epilepsy and treatment with Vigabatrin (VGB). VGB is an antiepileptic medication that is associated with visual field constriction.Methods. Thirty-one VGB patients and 10 control subjects, median age 6 years, were recruited. Visual field extent oil the major oblique meridia was tested with a 6 white sphere and WSKP, a method used by Quinn et: al. to study field extent in children with retinopathy of prematurity. The same meridia were tested using Goldmann kinetic perimetry (GKP; 1.7 degrees target) in those who were capable. Monocular and binocular tests were conducted. Visual field extent for WSKP and GKP were compared in VGB patients and control subjects.Results. Twenty-eight of 31 VGB patients were testable with binocular WSKP and their median visual field extents were smaller than controls. In 8 of 28 (29%) VGB patients, binocular field extents were smaller than the minimum in the control subjects. Monocular WSKP results did not differ between VGB patients and control subjects. Nine VGB patients were testable with both WSKP and GKP; visual field extents did riot differ between tests.Conclusions. WSKP is feasible in VGB patients, even in those with developmental delays. WSKP has the potential to detect visual field constriction associated with VGB use. (Optom Vis Sci 2009;86:767-773)