Developmental Control of Oocyte Maturation and Egg Activation in Metazoan Models
Developmental Control of Oocyte Maturation and Egg Activation in Metazoan Models
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DOI：
10.1101/cshperspect.a005553
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发表时间：
2011-10-01
影响因子：
7.2
通讯作者：
Orr-Weaver, Terry L.
中科院分区：
文献类型：
--
作者：
Von Stetina, Jessica R.;Orr-Weaver, Terry L.
功能性卵子的产生需要减数分裂与发育信号相协调。卵母细胞停滞在前期I以允许卵母细胞分化，并且在大多数动物中，第二次减数分裂停滞将减数分裂的完成与受精联系起来。哺乳动物、秀丽隐杆线虫和果蝇之间卵母细胞成熟和卵激活的比较揭示了保守的信号通路和调节机制以及对生殖策略的独特适应。最近的研究在哺乳动物和C。elegans显示了周围体细胞和卵母细胞之间的信号传导在维持前期I停滞和控制成熟中的作用。已在果蝇中鉴定了在前期I停滞期间调节活性Cdk 1/细胞周期蛋白B水平的蛋白质。蛋白激酶在C.线虫和果蝇。在这里，我们将对比卵母细胞减数分裂的关键事件的调控。
Production of functional eggs requires meiosis to be coordinated with developmental signals. Oocytes arrest in prophase I to permit oocyte differentiation, and in most animals, a second meiotic arrest links completion of meiosis to fertilization. Comparison of oocyte maturation and egg activation between mammals, Caenorhabditis elegans, and Drosophila reveal conserved signaling pathways and regulatory mechanisms as well as unique adaptations for reproductive strategies. Recent studies in mammals and C. elegans show the role of signaling between surrounding somatic cells and the oocyte in maintaining the prophase I arrest and controlling maturation. Proteins that regulate levels of active Cdk1/cyclin B during prophase I arrest have been identified in Drosophila. Protein kinases play crucial roles in the transition from meiosis in the oocyte to mitotic embryonic divisions in C. elegans and Drosophila. Here we will contrast the regulation of key meiotic events in oocytes.