Vitamin K and vitamin D status: Associations with inflammatory markers in the framingham offspring study
Vitamin K and vitamin D status: Associations with inflammatory markers in the framingham offspring study
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DOI：
10.1093/aje/kwm306
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发表时间：
2008-02-01
影响因子：
5
通讯作者：
Benjamin, Emelia J.
中科院分区：
文献类型：
--
作者：
Shea, M. Kyla;Booth, Sarah L.;Benjamin, Emelia J.
体外数据表明维生素 K 和 D 在炎症中发挥保护作用。为了研究维生素 K 和 D 与体内炎症之间的关联，作者使用了多元线性回归分析，并根据年龄、性别、体重指数、甘油三酯浓度、阿司匹林的使用、降脂药物的使用、季节、绝经状态和激素替代疗法进行了调整。参与者来自 Framingham 后代研究（1997-2001 年；n = 1,381；平均年龄 = 59 岁；52% 为女性）。通过血浆叶绿醌浓度和叶绿醌摄入量测量的维生素 K 状态与循环炎症标志物作为一个组和几个单独的炎症生物标志物呈负相关 (p < 0.01)。羧基化骨钙素不足的百分比（维生素 K 状态的功能测量）与整体炎症无关，但与 C 反应蛋白相关 (p < 0.01)。尽管血浆 25-羟基维生素 D 与尿异前列烷浓度（氧化应激指标）呈负相关 (p < 0.01)，但维生素 D 状态与炎症之间的总体关联并不一致。高维生素 K 状态与较低浓度的炎症标志物相关的观察结果表明，维生素 K 在炎症中可能具有的保护作用值得进一步研究。
In vitro data suggest protective roles for vitamins K and D in inflammation. To examine associations between vitamins K and D and inflammation in vivo, the authors used multiple linear regression analyses, adjusted for age, sex, body mass index, triglyceride concentrations, use of aspirin, use of lipid-lowering medication, season, menopausal status, and hormone replacement therapy. Participants were from the Framingham Offspring Study (1997-2001; n = 1,381; mean age = 59 years; 52% women). Vitamin K status, measured by plasma phylloquinone concentration and phylloquinone intake, was inversely associated with circulating inflammatory markers as a group and with several individual inflammatory biomarkers (p < 0.01). Percentage of undercarboxylated osteocalcin, a functional measure of vitamin K status, was not associated with overall inflammation but was associated with C-reactive protein (p < 0.01). Although plasma 25-hydroxyvitamin D was inversely associated with urinary isoprostane concentration, an indicator of oxidative stress (p < 0.01), overall associations between vitamin D status and inflammation were inconsistent. The observation that high vitamin K status was associated with lower concentrations of inflammatory markers suggests that a possible protective role for vitamin K in inflammation merits further investigation.