DETERMINATION EVENTS IN THE NERVOUS-SYSTEM OF THE VERTEBRATE EMBRYO
DETERMINATION EVENTS IN THE NERVOUS-SYSTEM OF THE VERTEBRATE EMBRYO
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DOI：
10.1016/0959-437x(95)90048-l
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发表时间：
1995-08-01
影响因子：
4
通讯作者：
WASSEF, M
中科院分区：
文献类型：
--
作者：
BALLYCUIF, L;WASSEF, M
分子和功能数据表明，脊椎动物胚胎脑（后脑）尾部的区域化是通过分割过程建立的。相比之下，位于更靠前侧的后脑中脑域（中后脑交界处）似乎遵循一种依赖于源自该域中心区域的远程诱导和组织活动的规范模式。最近针对这种前/后决定模式的研究表明 Wnt-1 是该过程中的关键参与者。
Molecular and functional data suggest that the regionalization of the caudal portion of the vertebrate embryonic brain (hindbrain) is set up through a process of segmentation. In contrast, the more rostrally located met-mesencephalic domain (mid-hindbrain junction) appears to follow a mode of specification that relies on long-range inducing and organizing activities originating from the central region of the domain. Recent studies addressing this mode of anterior/posterior determination point to Wnt-1 as a key player in this process.