Mapping of Transdiagnostic Neuropsychiatric Phenotypes Across Patients in Two General Hospitals.
Mapping of Transdiagnostic Neuropsychiatric Phenotypes Across Patients in Two General Hospitals.
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DOI：
10.1016/j.jaclp.2021.01.002
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发表时间：
2021-07
影响因子：
2.3
通讯作者：
McCoy TH
中科院分区：
文献类型：
--
作者：
Hart KL;Perlis RH;McCoy TH
多维transdiagnosis表型系统是越来越重要的神经精神表型，特别是在转化研究设置。NIMH研究领域标准（RDoC）的多维方法的精神病理学和非精神病诊断的关系还没有研究规模，但相关的医疗和外科环境中的神经精神疾病的护理。我们应用CQH Dimensional Phenotyper自然语言处理工具来估计两个大型学术综合医院在八年内每个非精神科病房收治的NIMH RDoC域相关症状。我们比较了模式，在个别领域的症状负担，以及一个新的合并一维措施，通过初级医疗和手术诊断。分析包括来自第一医院的227，243例患者，其中68，793例（30.3%）有既往精神病史，来自第二医院的220，213例患者，其中50，818例（23.1%）有既往精神病史。RDoC症状负担在主要诊断中的分布在医院站点之间相似，并且在主要内科或外科诊断之间存在显著差异。初步内科或外科诊断对RDoC症状负担的影响大于既往精神病史。根据综合医院患者的临床记录估计的基于RDoC的神经精神症状负担与初级医院内科或外科诊断的相关性比与既往精神病史的相关性更强。精神疾病和躯体疾病的双向作用需要通过转诊断表型的透镜进一步研究。
Multidimensional transdiagnostic phenotyping systems are increasingly important to neuropsychiatric phenotyping, particularly in translational research settings. The relationship the NIMH Research Domain Criteria (RDoC) multidimensional approach to psychopathology and nonpsychiatric diagnoses has not been studied at scale but is relevant to those caring for neuropsychiatric illness in medical and surgical settings. We applied the CQH Dimensional Phenotyper natural language processing tool to estimate NIMH RDoC domain associated symptoms of individuals admitted to nonpsychiatric wards at each of two large academic general hospitals over an eight-year period. We compared patterns in individual domain symptom burden, as well as a new pooled unidimensional measure, by primary medical and surgical diagnosis. Analysis included 227,243 patients from hospital 1 of whom 68,793 (30.3%) had a prior psychiatric history and 220,213 patients from hospital 2 of whom 50,818 (23.1%) had a prior psychiatric history. The distribution of RDoC symptom burdens over primary diagnosis was similar across hospital sites and differed significantly across primary medical or surgical diagnosis. The effect of primary medical or surgical diagnosis was larger than that of prior psychiatric history on RDoC symptom burden. RDoC based neuropsychiatric symptom burden estimated from general hospital patients’ clinical documentation is more strongly associated with the primary hospital medical or surgical diagnosis than it is with the presence of a previous psychiatric history. The bidirectional role of psychiatric and somatic illness warrants further study through the lens of transdiagnostic phenotyping.
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影响因子：
7
作者：
Barroilhet, Sergio A.;Bieling, Alexandra E.;McCoy, Thomas H., Jr.;Perlis, Roy H.
通讯作者：
Perlis, Roy H.
影响因子：
8.3
作者：
De Hert M;Detraux J;Vancampfort D
通讯作者：
Vancampfort D
影响因子：
3.7
作者：
McCoy, Thomas H.;Castro, Victor M.;Perlis, Roy H.
通讯作者：
Perlis, Roy H.
影响因子：
25.4
作者：
Clark, Lee Anna;Cuthbert, Bruce;Reed, Geoffrey M.
通讯作者：
Reed, Geoffrey M.
影响因子：
6.9
作者：
DEPAULO, JR;FOLSTEIN, MF;GORDON, B
通讯作者：
GORDON, B