Effects of cognitive-behavioral therapy on brain activation in specific phobia
Effects of cognitive-behavioral therapy on brain activation in specific phobia
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DOI：
10.1016/j.neuroimage.2005.07.007
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发表时间：
2006-01
期刊：
影响因子：
5.7
通讯作者：
T. Straube;Madlen Glauer;Stefan Dilger;H. Mentzel;W. Miltner
中科院分区：
文献类型：
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作者：
T. Straube;Madlen Glauer;Stefan Dilger;H. Mentzel;W. Miltner
关于成功的心理治疗对焦虑症患者大脑功能的影响，人们知之甚少。本研究旨在确定认知行为疗法(CBT)后患有特定恐惧症的受试者大脑激活的变化。采用功能磁共振成像(FMRI)技术，检测了28例蜘蛛恐惧症患者和14例正常对照组的大脑对蜘蛛视频的激活程度。恐惧症患者随机分为治疗组(TG)和等候名单对照组(WG)。两组恐惧症患者都接受了两次扫描。在扫描期间，将CBT给予TG。在治疗前，两组恐惧症患者的大脑激活情况没有差异。与对照组受试者相比，恐惧症患者在脑岛和前扣带回皮质(ACC)对蜘蛛视频的反应更强。CBT显著减轻了TG的恐怖症状，而WG组的行为没有变化。在第二次扫描中，与WG组相比，TG组的脑岛和ACC的过度活动显著减少。这些结果表明，脑岛和ACC的激活增加与特定的恐惧症有关，而这些大脑反应的减弱与成功的治疗干预有关。
Little is known about the effects of successful psychotherapy on brain function in subjects with anxiety disorders. The present study aimed to identify changes in brain activation following cognitive-behavioral therapy (CBT) in subjects suffering from specific phobia. Using functional magnetic resonance imaging (fMRI), brain activation to spider videos was measured in 28 spider phobic and 14 healthy control subjects. Phobics were randomly assigned to a therapy-group (TG) and a waiting-list control group (WG). Both groups of phobics were scanned twice. Between scanning sessions, CBT was given to the TG. Before therapy, brain activation did not differ between both groups of phobics. As compared to control subjects, phobics showed greater responses to spider vs. control videos in the insula and anterior cingulate cortex (ACC). CBT strongly reduced phobic symptoms in the TG while the WG remained behaviorally unchanged. In the second scanning session, a significant reduction of hyperactivity in the insula and ACC was found in the TG compared to the WG. These results propose that increased activation in the insula and ACC is associated with specific phobia, whereas an attenuation of these brain responses correlates with successful therapeutic intervention.