Birth weight in live births and stillbirths
Birth weight in live births and stillbirths
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DOI：
10.1002/uog.17287
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发表时间：
2016-11-01
影响因子：
7.1
通讯作者：
Nicolaides, K. H.
中科院分区：
文献类型：
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作者：
Poon, L. C. Y.;Tan, M. Y.;Nicolaides, K. H.
目的建立出生时胎龄体重的正常值范围，并与INTERGROWTH-21标准中小于胎龄儿（SGA）的活产和死胎比例进行比较。建立胎龄出生体重正常范围的纳入标准是表型正常的新生儿>= 24周妊娠的活产，排除标准是吸烟和孕前高血压、糖尿病、系统性红斑狼疮或抗磷脂综合征、先兆子痫、妊娠高血压、妊娠期糖尿病或因胎儿生长受限而导致的医源性早产。92018例活产符合入选标准。对出生体重<5和<10百分位数的活产和死产比例与按INTERGROWTH-21标准的活产和死产比例进行卡方检验和McNemar检验，并进行比较。根据我们的标准的第5百分位数显著高于根据INTERGROWTH-21标准的比例，且与之不一致（活产：5.6% vs 3.4%;死产：37.2% vs 22.7%）。同样，根据我们的标准，出生体重<第10百分位数的活产和死产比例显著高于根据INTERGROWTH-21标准的比例，且与之不一致（活产：11.2% vs 6.9%;死产：结论INTERGROWTH-21标准低估了我国人群中SGA活产和死产的比例。版权所有（C）2016 ISUOG.出版社：John Wiley & Sons Ltd
Objective To establish a normal range of birth weights for gestational age at delivery and to compare the proportion of live births and stillbirths that are classified as small-for-gestational age (SGA) according to our normal range vs that of the INTERGROWTH-21st standard.Methods The study population comprised 113 019 live births and 437 (0.4%) stillbirths. The inclusion criterion for establishing a normal range of birth weights for gestational age was the live birth of a phenotypically normal neonate >= 24 weeks' gestation and the exclusion criteria were smoking and prepregnancy hypertension, diabetes mellitus, systemic lupus erythematosus or antiphospholipid syndrome, pre-eclampsia, gestational hypertension, gestational diabetes mellitus or iatrogenic preterm birth for fetal growth restriction in the current pregnancy. Inclusion criteria were met by 92 018 live births. The proportions of live births and stillbirths with birth weights< 5th and < 10th percentiles of our normal range and those according to the INTERGROWTH-21st standard were determined and compared by the chi-square test and McNemar test.Results The proportions of live births and stillbirths with a birth weight < 5th percentile according to our standard were significantly higher than and discordant with the proportion according to the INTERGROWTH-21st standard (live birth: 5.6% vs 3.4%; stillbirth: 37.2% vs 22.7%). Similarly, the proportion of live births and stillbirths with a birth weight < 10th percentile according to our standard were significantly higher than and discordant with those according to the INTERGROWTH-21st standard (live birth: 11.2% vs 6.9%; stillbirth: 44.3% vs 32.6%).Conclusion The INTERGROWTH-21st standard underestimates the proportion of SGA live births and stillbirths in our population. Copyright (C) 2016 ISUOG. Published by John Wiley & Sons Ltd.