Hematological indices as simple, inexpensive and practical severity markers of obstructive sleep apnea syndrome: a meta-analysis
Hematological indices as simple, inexpensive and practical severity markers of obstructive sleep apnea syndrome: a meta-analysis
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DOI：
10.21037/jtd.2018.10.105
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发表时间：
2018-12-01
影响因子：
2.5
通讯作者：
Shen, Huahao
中科院分区：
文献类型：
--
作者：
Wu, Mindan;Zhou, Lingren;Shen, Huahao
背景资料：临床上检测炎症标志物有助于评估阻塞性睡眠呼吸暂停综合征（OSAS）患者夜间缺氧程度和预测并发症的发生。近年来，一些研究者提出用血液学指标代替新的疾病特异性生化指标（如C反应蛋白），因为它们相对便宜、简单、实用。方法：检索PubMed、Web of Science、Scopus、科克伦图书馆、临床试验、Embase和Google Scholar等医学数据库（截止2018年3月29日）。我们使用加权平均差（VVMDs）与95%置信区间（Cis）的随机效应model.Results：17个研究被纳入本荟萃分析，结果是由不同的血液学参数。汇总分析显示，OSAS与高水平的WBC相关（白色血细胞，11项研究，2，206名受试者，WMD：0.58; 95%CI：0.31至0.85; P
Background: Clinical detection of inflammatory markers is useful to assess the degree of nocturnal hypoxia and predict the presence of complications in obstructive sleep apnea syndrome (OSAS) patients. Nowadays, some researchers proposed that hematological parameters could be substituted for novel disease-specific biochemical markers (such as C-reactive protein) because they were comparatively cheap, simple and practical. But there was a contradiction whether the hematological parameters were positively correlated with the OSAS severity.Methods: Medical databases were searched included PubMed, Web of Science, Scopus, Cochrane Library, Clinical Trial, Embase and Google Scholar (up to March 29, 2018). We used weighted mean differences (VVMDs) with 95% confidence intervals (Cis) from random-effects model.Results: Seventeen studies were included in this meta-analysis and results were presented by different hematological parameters. Pooled analysis showed that OSAS was associated with a high level of WBC (white blood cell, 11 studies, 2,206 subjects, WMD: 0.58; 95% CI: 0.31 to 0.85; P