SIMILAR AMINO-ACID-SEQUENCES - CHANCE OR COMMON ANCESTRY
SIMILAR AMINO-ACID-SEQUENCES - CHANCE OR COMMON ANCESTRY
复制标题
DOI：
10.1126/science.7280687
复制
发表时间：
1981-01-01
期刊：
影响因子：
56.9
通讯作者：
DOOLITTLE, RF
中科院分区：
文献类型：
--
作者：
DOOLITTLE, RF
将每一个新确定的氨基酸序列与所有其他已知序列进行系统的比较，可以完全重建导致当代蛋白质的进化事件。但有时幸存的相似性是如此模糊，即使是基于计算机的序列比较程序也无法验证关系。在另一些情况下，完全不同的蛋白质中也可能出现类似的序列，这仅仅是偶然的结果，或者偶尔是由于具有特殊性质的序列的趋同进化。
The systematic comparison of every newly determined amino acid sequence with all other known sequences may allow a complete reconstruction of the evolutionary events leading to contemporary proteins. But sometimes the surviving similarities are so vague that even computer-based sequence comparison procedures are unable to validate relationships. In other cases similar sequences may appear in totally alien proteins as a result of mere chance or, occasionally, by the convergent evolution of sequences with special properties.