Indomethacin in ocular inflammation in rabbits.
Indomethacin in ocular inflammation in rabbits.
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吲哚美辛治疗兔眼部炎症。
DOI：
10.1001/archopht.1967.00980020556022
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发表时间：
1967
影响因子：
--
通讯作者：
H. Keatts
中科院分区：
文献类型：
--
作者：
C. Hanna;H. Keatts
在致敏兔眼内注射牛血清引起急性眼炎症。用氢化可的松或非甾体抗炎药吲哚美辛（indomethacin, Indocin）肌内或局部给药可显著降低兔的炎症程度。外用氢化可的松和吲哚美辛对兔角膜创面愈合无明显影响。吲哚美辛不能改变人疱疹病毒RE和PH株引起的角膜感染的过程，而氢化可的松使感染过程恶化。吲哚美辛和氢化可的松不抑制依多尿定对兔角膜疱疹的抗病毒作用。
Acute ocular inflammation was produced in sensitized rabbits by the intracameral injection of bovine serum. When the rabbits were treated with hydrocortisone or the nonsteroid anti-inflammatory agent, indomethacin (Indocin), by the intramuscular or topical route the degree of inflammation was markedly reduced. Topical hydrocortisone and indomethacin did not alter wound healing in the rabbit cornea. Indomethacin did not alter the course of corneal infection due to the RE and PH strains ofHerpesvirus hominis, whereas, hydrocortisone made the course of this infection worse. Indomethacin and hydrocortisone did not inhibit the antiviral effects of idoxuridine on herpetic keratitis of the rabbit cornea.