New predictors of disease - Molecules called predictive autoantibodies appear in the blood years before people show symptoms of various disorders. Tests that detected these molecules could warn of the need to take preventive action
New predictors of disease - Molecules called predictive autoantibodies appear in the blood years before people show symptoms of various disorders. Tests that detected these molecules could warn of the need to take preventive action
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DOI：
10.1038/scientificamerican0307-72
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发表时间：
2007-03-01
影响因子：
3
通讯作者：
Notkins, Abner Louis
中科院分区：
文献类型：
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作者：
Notkins, Abner Louis
某些自身抗体在疾病出现明显症状之前许多年就出现，这表明对这些分子的筛查可用于预测谁有患病的风险。在自身免疫性疾病中，例如 I 型糖尿病，免疫系统会错误地产生针对身体组织的抗体。自身抗体还可以作为疾病严重程度和进展的指南，甚至可以警告某些非免疫性疾病的风险。预测性自身抗体筛查有一天可能会成为常规，尽管目前缺乏预防性治疗措施。
Certain autoantibodies appear many years before overt symptoms of disease, suggesting that screening for these molecules could be used to predict who is at risk of falling ill. In autoimmune diseases, such as type I diabetes, the immune system mistakenly manufactures antibodies that target the body's tissues. Autoantibodies might also serve as guides to disease severity and progression and might even warn of risk for some nonimmune disorders. Screening for predictive autoantibodies could one day become routine, although a dearth of preventive treatments currently stands in the way.