Seroepidemiology of group I human coronaviruses in children
Seroepidemiology of group I human coronaviruses in children
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DOI：
10.1016/j.jcv.2007.08.007
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发表时间：
2007-11-01
影响因子：
8.8
通讯作者：
Kahn, Jeffrey S.
中科院分区：
文献类型：
--
作者：
Shao, Xiuping;Guo, Xiaojie;Kahn, Jeffrey S.
背景：近年来发现了几种新的人类冠状病毒。目的：明确I组人类冠状病毒的血清流行病学。研究设计：应用重组蛋白酶联免疫吸附试验（ELISA）检测了243例儿童和青壮年血清中HCoV-229 E的阳性率为57. 3%。婴儿1%
Background: Recently, several new human coronaviruses have been identified.Objectives: To define the seroepidemiology of group I human coronaviruses. Study design: A recombinant protein enzyme linked immunosorbent assay (ELISA) based on portions of the nucleocapsid protein of group I human coronaviruses was developed and was used to screen serum from 243 children and young adults.Results: For HCoV-229E, the percentages of seropositive individuals were 57. 1 % for infants