Synthesis of 2′-β-C-methyl toyocamycin and sangivamycin analogues as potential HCV inhibitors
Synthesis of 2′-β-C-methyl toyocamycin and sangivamycin analogues as potential HCV inhibitors
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DOI：
10.1016/j.bmcl.2004.11.019
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发表时间：
2005-02-01
影响因子：
2.7
通讯作者：
Girardet, JL
中科院分区：
文献类型：
--
作者：
Ding, YL;An, HY;Girardet, JL
Coupling reaction of 2-beta-C-methyl-1,2,3,4-tetra-O-benzoyl-D-ribofuranose with 4-amino-6-bromo-5-cyanopyrrolo[2,3-(d)]pyrimidine, followed by debromination and debenzoylation, gave the 2'-beta-C-methyl toyocamycin in high yield. Based on this result. a series of 2'-beta-C-methyl-4-substituted toyocamycin and sangivamycin analogues were synthesized for biological screening as potential inhibitors of HCV RNA replication. (C) 2004 Elsevier Ltd. All rights reserved.
