Recollective qualities modulate hippocampal activation during autobiographical memory retrieval
Recollective qualities modulate hippocampal activation during autobiographical memory retrieval
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DOI：
10.1002/hipo.10215
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发表时间：
2004-01-01
期刊：
影响因子：
3.5
通讯作者：
McAndrews, MP
中科院分区：
文献类型：
--
作者：
Addis, DR;Moscovitch, M;McAndrews, MP
最近的神经影像学研究报告优先海马参与自传体记忆（AM）检索。尽管这种优先激活的基础尚不清楚，但它可能与AM的时间特异性、近因性或回忆品质有关，例如细节、情感和个人意义。然而，通常情况下，这些变量是混淆的，因此，我们试图调查的贡献，每个海马激活在AM检索。我们进行了一项与事件相关的功能性磁共振成像（fMRI）研究，参与者检索了时间特异性AM和一般重复AM，并对每个AM的详细程度、情感或个人意义进行了评级。这些评级，以及近的AM，被用于参数调制分析，以确定与评级，独立的近，反之亦然正相关的大脑区域。提取AM激活了许多区域，包括海马体。具体和一般AM检索之间海马激活没有明显差异，这表明时间特异性本身并不是海马激活的关键调节因子。激活的左海马在特定的上午检索的细节，个人的意义，并在阈下水平，情绪，当近因的影响是协变的。此外，在一般上午检索，所有三个回忆的质量调制活动在右侧海马。虽然特定AM的新近调制海马激活双边，这种效果消散在左侧海马时，细节或情绪作为协变量，并不再存在于任何海马时，考虑到个人的意义。我们的研究结果表明，回忆品质是重要的预测海马参与在AM检索独立的因素，如近因。这些发现与海马功能理论相一致，强调其在回忆多方面自传体经历中的作用。(C)2004 Wiley-Liss，Inc.
Recent neuroimaging studies report preferential hippocampal engagement during autobiographical memory (AM) retrieval. Although the basis of this preferential activation remains unclear, it may be related to the temporal specificity, recency, or recollective qualities of AMs, such as detail, emotionality, and personal significance. Typically, however, these variables are confounded, and thus we sought to investigate the contributions of each to hippocampal activation during AM retrieval. We conducted an event-related functional magnetic resonance imaging (fMRI) study in which participants retrieved temporally specific AMs and general, repeated AMs, and rated each for level of detail, emotion, or personal significance. These ratings, as well as the recency of AMs, were used in parametric modulation analyses to identify brain regions that correlated positively with ratings, independent of recency, and vice versa. Retrieval of AMs activated a number of regions, including the hippocampus. No differences in hippocampal activation were evident between specific and general AM retrieval, suggesting that temporal specificity, on its own, is not a key modulator of hippocampal activation. Activation of the left hippocampus during specific AM retrieval did vary with the level of detail, personal significance, and at a subthreshold level, emotionality, when the effect of recency was covaried out. Further, during general AM retrieval, all three recollective qualities modulated activity in the right hippocampus. Although the recency of specific AMs modulated hippocampal activation bilaterally, this effect dissipated in the left hippocampus when detail or emotionality was included as a covariate, and was no longer present in either hippocampus when personal significance was taken into account. Our results suggest that recollective qualities are important predictors of hippocampal engagement during AM retrieval independent of factors such as recency. These findings are consistent with theories of hippocampal function that emphasize its role in the recollection of multifaceted autobiographical experiences. (C) 2004 Wiley-Liss, Inc.