Folate deficiency in depressive illness.
Folate deficiency in depressive illness.
复制标题
抑郁症中叶酸缺乏。
DOI：
10.1192/bjp.117.538.287
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发表时间：
1970
期刊：
影响因子：
--
通讯作者：
A. Coppen
中科院分区：
文献类型：
--
作者：
E. Reynolds;J. Preece;J. Bailey;A. Coppen
Serum folate and vitamin B12 levels have been measured in 101 patients with depressive illness. Subnormal folate levels (2.5 ng./ml. or less) were found in 24 per cent and subnormal vitamin B12 levels (150 pg./ml. or less) in 2.2 per cent of patients. Thirteen patients(14.4 per cent) had low vitamin B12 levels (200 pg./ml. or less). Patients with subnormal folate levels were found to have significantly higher depressive scores, and significantly lower validity scores on the Marke-Nyman Temperament Scale, both on admission and on discharge. Subnormal folate levels could be a consequence of dietary deficiency or could possibly be causal of depression through interference with tyrosine or tryptophan hydroxylation.
