Recent emergence of the Arctic rabies virus lineage
Recent emergence of the Arctic rabies virus lineage
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DOI：
10.1016/j.virusres.2011.10.026
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发表时间：
2012-01-01
期刊：
影响因子：
5
通讯作者：
Wandeler, Alexander I.
中科院分区：
文献类型：
--
作者：
Nadin-Davis, Susan A.;Sheen, Mary;Wandeler, Alexander I.
在北极国家以及北亚和中亚大部分地区传播的狂犬病病毒在系统发育上密切相关，统称为北极/类北极 (AL) 谱系。鉴于狂犬病在亚洲许多地区仍然是一种严重的人畜共患疾病，尤其是在印度，狂犬病的流行导致人类频繁接触狂犬病并导致死亡，因此该谱系的出现和传播引起了人们的极大关注。此前对印度狂犬病病毒的分子流行病学研究表明，AL 谱系是在该国大部分地区流行的病毒类型。为了进一步探讨印度和北极狂犬病病毒的关系，对从印度北部拉贾斯坦邦回收的一组样本的 N 基因位点进行了表征。将这些数据与来自印度、中亚/北亚和北极的大量样本相结合，可以对该病毒谱系进行详细的系统发育分析，并估计其出现的时间范围。这些分析表明，大多数当前的印度病毒是在过去 40 年内出现的，而整个北极/AL 谱系是在过去 200 年内出现的，这一时间范围与北极分支入侵加拿大的历史记录一致。皇冠版权所有 (C) 2011 由 Elsevier B.V. 出版。保留所有权利。
The rabies viruses that circulate in Arctic countries and in much of northern and central Asia are phylogenetically closely related and collectively referred to as the Arctic/Arctic-like (AL) lineage. The emergence and spread of this lineage is of significant interest given that rabies remains a serious zoonotic disease in many parts of Asia, especially in India where the prevalence of dog rabies leads to frequent human exposures and deaths. Previous molecular epidemiological studies of rabies viruses in India identified the AL lineage as the type circulating across much of the country. To further explore the relationship of Indian and Arctic rabies viruses, a collection of samples recovered from Rajasthan state in northern India was characterised at the N gene locus. Combination of these data with a larger collection of samples from India, central/northern Asia and the Arctic has permitted detailed phylogenetic analysis of this viral lineage and estimation of its time-frame of emergence. These analyses suggest that most current Indian viruses emerged from a common progenitor within the last 40 years and that the entire Arctic/AL lineage emerged within the last 200 years, a time-frame in accord with historical records of the invasion of Canada by the Arctic clade. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.