Thrombin-activatable fibrinolysis inhibitor.
Thrombin-activatable fibrinolysis inhibitor.
复制标题
凝血酶激活的纤溶抑制剂。
DOI：
10.2174/0929867043364586
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发表时间：
2004
影响因子：
4.1
通讯作者：
P. Marx
中科院分区：
文献类型：
--
作者：
P. Marx
凝血系统是防止血管损伤后失血的有效机制。它由许多连接的酶反应组成，导致凝血酶的产生。凝血酶将可溶性纤维蛋白原转化为纤维蛋白凝块。伤口愈合后，血凝块随后被纤溶系统去除。凝血酶激活的纤溶抑制剂 (TAFI) 与之前鉴定的蛋白质原羧肽酶 B、R 和 U 相同，在血液凝固和纤溶之间形成联系。 TAFI 在血流中作为非活性酶原循环，并在血液凝固过程中被激活。活性形式 TAFIa 通过从部分降解的纤维蛋白中切下 C 末端赖氨酸残基来抑制纤维蛋白溶解，从而刺激组织型纤溶酶原激活剂介导的纤溶酶原向纤溶酶的转化。因此，去除这些赖氨酸会减少纤溶酶的形成，从而保护纤维蛋白凝块免于分解。此外，TAFI 还可能在炎症和组织修复等其他过程中发挥作用。在这篇综述中，讨论了 TAFI 研究的最新进展。
The coagulation system is a potent mechanism that prevents blood loss after vascular injury. It consists of a number of linked enzymatic reactions resulting in thrombin generation. Thrombin converts soluble fibrinogen into a fibrin clot. The clot is subsequently removed by the fibrinolytic system upon wound healing. Thrombin-activatable fibrinolysis inhibitor (TAFI), which is identical to the previously identified proteins procarboxypeptidase B, R, and U, forms a link between blood coagulation and fibrinolysis. TAFI circulates as an inactive proenzyme in the bloodstream, and becomes activated during blood clotting. The active form, TAFIa, inhibits fibrinolysis by cleaving off C-terminal lysine residues from partially degraded fibrin that stimulates the tissue-type plasminogen activator-mediated conversion of plasminogen to plasmin. Consequently, removal of these lysines leads to less plasmin formation and subsequently to protection of the fibrin clot from break down. Moreover, TAFI may also play a role in other processes such as, inflammation and tissue repair. In this review, recent developments in TAFI research are discussed.