INFECTIOUS RESERVOIR OF PLASMODIUM-VIVAX AND PLASMODIUM-FALCIPARUM MALARIA IN AN ENDEMIC REGION OF SRI-LANKA
INFECTIOUS RESERVOIR OF PLASMODIUM-VIVAX AND PLASMODIUM-FALCIPARUM MALARIA IN AN ENDEMIC REGION OF SRI-LANKA
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DOI：
10.4269/ajtmh.1991.45.479
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发表时间：
1991-10-01
影响因子：
3.3
通讯作者：
MENDIS, KN
中科院分区：
文献类型：
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作者：
GAMAGEMENDIS, AC;RAJAKARUNA, J;MENDIS, KN
通过在 17 个月的时间内直接以受感染个体的样本为蚊子喂食，确定了斯里兰卡疟疾流行地区的间日疟原虫和恶性疟原虫的传染性储存库，该群体为 3, 625 人。同时监测该人群的疟疾病例发病率。间日疟原虫配子体密度在最年轻的年龄组中最高，并随着年龄的增加而稳定下降。然而，年轻年龄组中每个配子细胞的感染性似乎低于年长组。患者年龄与恶性疟原虫配子体密度之间没有显着相关性，该人群最近才接触恶性疟原虫，不同年龄组中每个配子体的感染性也没有明显的趋势。最年轻（0-5岁）和最年长（> 50岁）年龄组患者的平均传染性最低。估计了不同年龄组的间日疟原虫患者对感染库的贡献。 6-25岁年龄组的患者对储存库的贡献最大，其次是26-50岁年龄组的患者。最年轻和最年长年龄组的患者对传染源的贡献最小。当考虑到不同年龄组的人口规模时，6岁至50岁之间的年龄组几乎同等地占据了约87%的传染源。恶性疟原虫疟疾的储存库非常小，仅限于 9% 的患者，这似乎是流行性疟疾的一个特征，恶性疟原虫也是如此。
The infectious reservoir of Plasmodium vivax and P. falciparum in a malaria endemic region in Sri Lanka was defined in a population of 3, 625 by directly feeding mosquitoes on a sample of infected individuals during a period of 17 months. The malaria case incidence in this population was concurrently monitored. P. vivax gametocyte densities were highest in the youngest age groups, and decreased steadily with increasing age. However, the infectivity per gametocyte appeared to be lower in the younger age groups than in the older ones. There was no significant correlation between the age of patients and their gametocyte densities for P. falciparum, to which this population was only recently exposed, nor was there a discernible trend in the infectivity per gametocyte in different age groups. The average infectivity of patients was lowest in the youngest (0-5 years) and the oldest (> 50) age groups. The contribution made by P. vivax patients in the different age groups to the reservoir of infection was estimated. Patients in the 6-25 year age groups made the largest contribution to the reservoir, followed by those in the 26- 50 year age group. Patients in the youngest and the oldest age groups contributed least to the infectious reservoir. When population sizes in the different age groups were taken into consideration, the age groups between 6 and 50 years contributed almost equally to approximately 87% of the infectious reservoir. The reservoir of P. falciparum malaria was very small, being confined to 9% of the patients, and this appears to be a characteristic of epidemic malaria, as was the case with P. falciparum.