Modulation of M1 and M2 muscarinic receptor subtypes following repeated organophosphate exposure in rats.
Modulation of M1 and M2 muscarinic receptor subtypes following repeated organophosphate exposure in rats.
复制标题
大鼠反复接触有机磷后 M1 和 M2 毒蕈碱受体亚型的调节。
DOI：
10.1016/0041-008x(92)90226-i
复制
发表时间：
1992
影响因子：
3.8
通讯作者：
Costa,LG
中科院分区：
文献类型：
--
作者：
Fitzgerald,BB;Costa,LG
Repeated exposure to organophosphates has been shown to cause a decrease in muscarinic cholinergic receptors in the central and peripheral nervous system. The present study measured the modulation of M1 and M2 muscarinic receptor subtypes in rat brain areas during and following a 2-week daily exposure to the organophosphate disulfoton. The radioligands [3H]telenzepine and [3H]AFDX 384 were utilized to label M1 and M2 receptors, respectively. The study found comparable down-regulation in both [3H]telenzepine- and [3H]AFDX 384-labeled receptors in cortex, hippocampus, and striatum during exposure. Recovery of M2 subtype was slower than recovery of M1, especially in the hippocampus. The results suggest that M1 and M2 receptor subtypes may be similarly regulated in response to subchronic exposure to organophosphates, but that recovery of receptor subtypes to control levels may be governed by distinct factors.
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影响因子：
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作者：
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DOI：
--
发表时间：
1991
期刊：
Research communications in chemical pathology and pharmacology
影响因子：
--
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Costa,LG
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影响因子：
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卡巴胆碱和去甲肾上腺素刺激大鼠脑中磷酸肌醇代谢：慢性胆碱酯酶抑制的作用。
DOI：
--
发表时间：
1986
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Costa,LG;Kaylor,G;Murphy,SD
通讯作者：
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