MITOTIC ABILITY OF LEUKEMIC LEUKOCYTES IN CHRONIC MYELOCYTIC LEUKEMIA.
MITOTIC ABILITY OF LEUKEMIC LEUKOCYTES IN CHRONIC MYELOCYTIC LEUKEMIA.
复制标题
慢性粒细胞白血病中白血病白细胞的有丝分裂能力。
作者：
A. Sandberg;Y. Kikuchi;L. Crosswhite
摘要 慢性粒细胞白血病 (CML) 患者的白血病血白细胞的体外培养表明，它们能够在缺乏植物血凝素的情况下分裂。在后者存在的情况下，这些受试者血液中的淋巴细胞优先被刺激进入有丝分裂。在缺乏促有丝分裂刺激剂的情况下，仅未成熟的白血病粒细胞进行分裂。 CML中的白血病白细胞在没有外源有丝分裂剂的情况下体外分裂的能力是Ph 1阳性和Ph 1阴性CML细胞的特征。结果表明，CML 患者血液中的未成熟粒细胞，以及非白血病受试者血液中的未成熟粒细胞，能够在没有外源有丝分裂物质的情况下分裂。
Summary In vitro culture of leukemic blood leukocytes from patients with chronic myelocytic leukemia (CML) showed them to be capable of division in the absence of phytohemagglutinin. In the presence of the latter, lymphocytes in the blood of these subjects were preferentially stimulated into mitosis. In the absence of the mitogenic stimulant only the immature leukemic granulocytic cells underwent division. The capacity of the leukemic leukocytes in CML to divide in vitro without an exogenous mitogenic agent was a characteristic of both Ph 1 -positive and Ph 1 -negative CML cells. The results indicate that immature granulocytic cells in the blood of patients with CML, and possibly in the blood of nonleukemic subjects, are capable of division without exogenous mitogenic substances.