Autoantigenic histone epitopes: a comparison between procainamide- and hydralazine-induced lupus.
Autoantigenic histone epitopes: a comparison between procainamide- and hydralazine-induced lupus.
复制标题
自身抗原组蛋白表位:普鲁卡因酰胺和肼屈嗪诱导的狼疮之间的比较。
DOI:
10.1002/art.1780300612
复制
发表时间:
1987
影响因子:
--
通讯作者:
Hardin,JA
中科院分区:
文献类型:
--
作者:
Craft,JE;Radding,JA;Harding,MW;Bernstein,RM;Hardin,JA
Using the technique of immunoblotting, we assessed the ability of sera from 19 patients with drug‐induced lupus to bind individual histones and specific histone fragments. The pattern of histone epitopes bound by sera from 9 patients with procainamide‐induced lupus was very similar to that described previously in spontaneous systemic lupus erythematosus. In contrast, sera from 10 patients with hydralazine‐induced lupus bound a broader array of individual histones and recognized a different set of histone epitopes. We conclude that these 2 drugs induce antihistone antibodies through somewhat different mechanisms, which possibly involve differences in their ability to structurally alter chromatin.
登录
查看更多内容
影响因子:
4.4
作者:
J. Portanova;R. Arndt;E. Tan;B. Kotzin
通讯作者:
B. Kotzin
影响因子:
4.4
作者:
J. Gohill;P. Cary;M. Couppez;M. Fritzler
通讯作者:
M. Fritzler
影响因子:
3.5
作者:
Jean O. Thomas;C. M. Wilson;J. Hardin
通讯作者:
J. Hardin
影响因子:
--
作者:
R. Bernstein;R. Hobbs;D. J. Lea;D. Ward;G. Hughes
通讯作者:
G. Hughes
影响因子:
11.4
作者:
S. Muller;K. Himmelspach;M. V. van Regenmortel
通讯作者:
M. V. van Regenmortel