Whole Body MRI at 3T with Quantitative Diffusion Weighted Imaging and Contrast-Enhanced Sequences for the Characterization of Peripheral Lesions in Patients with Neurofibromatosis Type 2 and Schwannomatosis.
Whole Body MRI at 3T with Quantitative Diffusion Weighted Imaging and Contrast-Enhanced Sequences for the Characterization of Peripheral Lesions in Patients with Neurofibromatosis Type 2 and Schwannomatosis.
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DOI：
10.5402/2013/627932
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发表时间：
2013-01-01
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影响因子：
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通讯作者：
Jacobs, Michael A
中科院分区：
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作者：
Fayad, Laura M;Blakeley, Jaishri;Jacobs, Michael A
目的。WB-MRI主要用于肿瘤的检测和监测。本研究的目的是建立WB-MRI在3T时对2型神经纤维瘤病（NF-2）和神经鞘瘤病患者进行病变表征的可行性，并结合DWI/ adc作图和对比增强序列。材料与方法。在3T时，对11名受试者（10名NF-2和1名神经鞘瘤患者）进行了WB-MRI检查，并进行了STIR、T1、增强T1和DWI/ADC成像（b = 50、400、800s/mm(2)）。两位读者回顾了周围病变的存在和特征的影像学。记录病变大小和特征（信号强度、异质性、增强特征和ADC值）。进行描述性统计。结果。共发现病灶23个，平均大小4.6 ±2.8cm。对比增强（肿瘤强化，囊肿无强化）表现为肿瘤（21/23）或囊肿（2/23）。T1时，肿瘤呈均匀等影（5/21）或低影（16/21）；STIR显示肿瘤呈高强度、均匀性（10/21）或异质性（11/21）；对比后T1，肿瘤呈均匀增强（14/21）或非均匀增强（7/21）；在DWI上，肿瘤ADC值是可变的（范围在0.8-2.7之间），表明肿瘤的内在特性是可变的。结论。在3T处进行定量DWI和对比增强序列的WB-MRI是可行的，它不仅促进了WB-MRI的检测，而且为病变表征提供了额外的指标。
Purpose. WB-MRI is mainly used for tumor detection and surveillance. The purpose of this study is to establish the feasibility of WB-MRI at 3T for lesion characterization, with DWI/ADC-mapping and contrast-enhanced sequences, in patients with neurofibromatosis type 2 (NF-2) and schwannomatosis. Materials and Methods. At 3T, WB-MRI was performed in 11 subjects (10 NF-2 and 1 schwannomatosis) with STIR, T1, contrast-enhanced T1, and DWI/ADC mapping (b = 50, 400, 800s/mm(2)). Two readers reviewed imaging for the presence and character of peripheral lesions. Lesion size and features (signal intensity, heterogeneity, enhancement characteristics, and ADC values) were recorded. Descriptive statistics were reported. Results. Twenty-three lesions were identified, with average size of 4.6 ± 2.8cm. Lesions were characterized as tumors (21/23) or cysts (2/23) by contrast-enhancement properties (enhancement in tumors, no enhancement in cysts). On T1, tumors were homogeneously isointense (5/21) or hypointense (16/21); on STIR, tumors were hyperintense and homogeneous (10/21) or heterogeneous (11/21); on postcontrast T1, tumors enhanced homogeneously (14/21) or heterogeneously (7/21); on DWI, tumor ADC values were variable (range 0.8-2.7), suggesting variability in intrinsic tumor properties. Conclusion. WB-MRI with quantitative DWI and contrast-enhanced sequences at 3T is feasible and advances the utility of WB-MRI not only to include detection, but also to provide additional metrics for lesion characterization.