The Mucins
The Mucins
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DOI：
10.1016/b978-0-12-374279-7.02019-1
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发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Hansson, Gunnar C.
中科院分区：
文献类型：
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作者：
Johansson, Malin E. V.;Hansson, Gunnar C.
粘蛋白是一个大糖蛋白家族，其特征是丰富的O-聚糖聚集在长粘蛋白结构域中。这些结构域是延伸的刚性杆，聚糖指向所有方向。这种聚糖簇使得蛋白酶无法接近中心蛋白质核心，并产生成簇抗原的聚糖表面。粘蛋白主要有两类：经典的凝胶形成聚合粘蛋白（MUC 2、MUC 5AC、MUC 5 B和MUC 6）和更异质的单体跨膜粘蛋白（MUC 1、MUC 3、MUC 4、MUC 12、MUC 13、MUC 15、MUC 16、MUC 17、MUC 20和MUC 21）。大多数粘蛋白存在于身体的粘膜表面，在那里它们构建保护性粘液和上皮细胞糖萼。其他粘蛋白，例如MUC 1，在身体的许多细胞中具有更广泛的分布，包括经典的免疫细胞。
The mucins are a family of large glycoproteins characterized by abundant O-glycans clustered in long mucin domains. These domains are extended stiff rods with the glycans pointing in all directions. This cluster of glycans makes the central protein core inaccessible to proteases and generates a glycan surface of clustered antigens. There are two main groups of mucins; the classical gel-forming polymeric mucins (MUC2, MUC5AC, MUC5B, and MUC6) and a more heterogeneous group of monomeric transmembrane mucins (MUC1, MUC3, MUC4, MUC12, MUC13, MUC15, MUC16, MUC17, MUC20, and MUC21). A majority of the mucins are found at the mucosal surfaces of the body where they build the protective mucus and the epithelial cell glycocalyx. Other mucins, for example, MUC1, have wider distribution to many cells of the body including classical immune cells.