Hemoglobin levels and skeletal muscle: results from the InCHIANTI study.
Hemoglobin levels and skeletal muscle: results from the InCHIANTI study.
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血红蛋白水平和骨骼肌：InCHIANTI 研究的结果。
DOI：
10.1093/gerona/59.3.m249
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Ferrucci,Luigi
中科院分区：
文献类型：
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作者：
Cesari,Matteo;Penninx,BrendaWJH;Lauretani,Fulvio;Russo,CosimoR;Carter,Christy;Bandinelli,Stefania;Atkinson,Hal;Onder,Graziano;Pahor,Marco;Ferrucci,Luigi
背景：贫血与体能和肌肉力量下降有关。本研究的目的是探讨是否贫血和血红蛋白水平与肌肉和脂肪的定量和定性措施的差异。方法。研究样本包括909名参加者65岁及以上的“Invecchiare在基安蒂”（InCHIANTI）研究，一个前瞻性的老年人为基础的研究，旨在确定老年残疾的危险因素。所有的分析都是考虑连续血红蛋白水平以及二分贫血变量（根据世界卫生组织标准定义为女性血红蛋白<12 g/dL和男性<13 g/dL）进行的。对所有参与者进行外周定量计算机断层扫描（pQCT），以评估小腿的总面积、肌肉面积和脂肪横截面积以及相对肌肉密度。使用手持式测力计测量踝关节伸展强度。在调整人口统计学、慢性病、药物使用和其他生物学变量后，使用线性回归分析评估pQCT和骨骼肌强度指标与血红蛋白水平和贫血的多变量关系。在我们的样本中，94名参与者（10.3%）贫血。血红蛋白水平与肌肉密度（β = 0.225 [SE，标准误0.098]，p= 0.02）、肌肉面积/总面积比（β = 0.778 [SE 0.262]，p= 0.003）、脂肪面积/总面积比（β =-0.869 [SE 0.225];p<0.001）显著相关。骨骼肌强度和肌肉密度与贫血高度相关（分别为β =-3.266 [SE 1.173]，p= 0.005和β =-0.816 [SE 0.374]，p= 0.03）。结果并没有改变时，分析在一个有限的样本中的参与者不受主要的医疗conditions.Conclusion.The本研究表明，血红蛋白水平与pQCT获得的身体成分的参数，并在肌肉力量的措施发生贫血的存在下，减少。
Background.Anemia is associated with reduced physical performance and muscle strength. The aim of the study was to explore whether anemia and hemoglobin levels are associated with differences in quantitative and qualitative measures of muscle and fat.Methods.The study sample consisted of 909 participants 65 years and older enrolled in the “Invecchiare in Chianti” (InCHIANTI) study, a prospective population-based study of older people aimed at identifying risk factors for late-life disability. All the analyses were performed considering continuous hemoglobin levels as well as the dichotomous anemia variable (defined according to World Health Organization criteria as hemoglobin <12 g/dL in women and <13 g/dL in men). A peripheral quantitative computed tomography (pQCT) scan was performed in all participants to evaluate total, muscular, and fat cross-sectional areas of the calf and relative muscle density. Ankle extension strength was measured using a hand-held dynamometer. Linear regression analyses were used to assess the multivariate relationship of pQCT and skeletal muscle strength measures with hemoglobin levels and anemia after adjustment for demographics, chronic conditions, medication use, and other biological variables.Results.Participants were aged 74.8 ± 6.8 years. In our sample, 94 participants (10.3%) were anemic. Hemoglobin levels were significantly associated with muscle density (β = 0.225 [SE, standard error 0.098],p=.02), muscle area/total area ratio (β = 0.778 [SE 0.262],p=.003), fat area/total area ratio (β = −0.869 [SE 0.225];p<.001). Skeletal muscle strength and muscle density were highly associated with anemia (β = −3.266 [SE 1.173],p=.005 and β = −0.816 [SE 0.374],p=.03, respectively). Results did not change when analyses were rerun in a restricted sample of participants not affected by major medical conditions.Conclusion.The present study shows that hemoglobin levels are associated with the parameters of body composition obtained by pQCT, and that decreases in muscular strength measures occur in the presence of anemia.