Comparison of the complete DNA sequences of human herpesvirus 6 variants A and B
Comparison of the complete DNA sequences of human herpesvirus 6 variants A and B
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DOI：
10.1128/jvi.73.10.8053-8063.1999
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发表时间：
1999-10-01
影响因子：
5.4
通讯作者：
Yamanishi, K
中科院分区：
文献类型：
--
作者：
Isegawa, Y;Mukai, T;Yamanishi, K
人类疱疹病毒6型（human herpesvirus 6，HHV-6）属于β疱疹病毒亚科，在体外主要感染T细胞，可引起急性和潜伏性感染。HHV-6的两种变体已根据几种性质的差异加以区分。我们测定了HHV-6变异株B（HHV-6 B）HST株的DNA全序列，并与变异株A株U1102的序列进行了比较。在整个HHV-6基因组的161，573-bp连续序列中共鉴定出115个潜在的开放阅读框架（ORF），包括一些在氨基酸同一性上具有显著差异的基因。所有的基因
Human herpesvirus 6 (HHV-6), which belongs to the betaherpesvirus subfamily and infects mainly T cells in vitro, causes acute and latent infections. Two variants of HHV-6 have been distinguished on the basis of differences in several properties. We have determined the complete DNA sequence of HHV-6 variant B (HHV-6B) strain HST, the causative agent of exanthem subitum, and compared the sequence with that of variant A strain U1102. A total of 115 potential open reading frames (ORFs) were identified within the 161,573-bp contiguous sequence of the entire HHV-6 genome, including some genes with remarkable differences in amino acid identity. All genes with