Roles of autophagy in elimination of intracellular bacterial pathogens.
Roles of autophagy in elimination of intracellular bacterial pathogens.
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DOI：
10.3389/fimmu.2013.00097
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发表时间：
2013
影响因子：
7.3
通讯作者：
Sasakawa C
中科院分区：
文献类型：
--
作者：
Jo EK;Yuk JM;Shin DM;Sasakawa C
作为一种基本的细胞内分解代谢过程，自噬对于在各种应激条件下消除蛋白质聚集体和受损的细胞质细胞器非常重要并且是必需的。自噬现在被认为是先天免疫的重要组成部分。即微生物的识别、选择性靶向和消除。由于其在先天免疫系统中的关键作用，通过自噬激活来靶向细菌的治疗可能被证明是对抗细胞内感染的有用策略。然而，重要的问题仍然存在，包括哪些分子对于自噬的细菌靶向至关重要，以及哪些机制参与细胞内微生物的自噬清除。在这篇综述中，我们讨论了抗菌自噬在细胞内细菌感染（分枝杆菌、沙门氏菌、志贺氏菌、李斯特菌和军团菌）中的作用，并提供了支持驱动自噬靶向细菌并消除入侵病原体的分子机制的最新证据。
As a fundamental intracellular catabolic process, autophagy is important and required for the elimination of protein aggregates and damaged cytosolic organelles during a variety of stress conditions. Autophagy is now being recognized as an essential component of innate immunity; i.e., the recognition, selective targeting, and elimination of microbes. Because of its crucial roles in the innate immune system, therapeutic targeting of bacteria by means of autophagy activation may prove a useful strategy to combat intracellular infections. However, important questions remain, including which molecules are critical in bacterial targeting by autophagy, and which mechanisms are involved in autophagic clearance of intracellular microbes. In this review, we discuss the roles of antibacterial autophagy in intracellular bacterial infections (Mycobacteria, Salmonella, Shigella, Listeria, and Legionella) and present recent evidence in support of molecular mechanisms driving autophagy to target bacteria and eliminate invading pathogens.